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Invitrogen
GRPR Recombinant Rabbit Monoclonal Antibody (18H31L38)
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FIGURE: 1 / 3
GRPR Antibody (703928) in ICC/IF
HEK-293 cells transiently transfected with GRPR were grown on poly-L-lysine-coated coverslips overnight. After 24 h, cells were fixed with 4% paraformaldehyde and 0.2% picric acid in phosphate buffer (pH 6.9) for 30 min at room temperature and washed several times with phosphate buffer. Specimens were permeabilized with ice-cold methanol and then incubated with Anti-GRPR Recombinant Rabbit Monoclonal Antibody (Product # 703928, 1:500 dilution). Cells were then incubated with Alexa 488-conjugated secondary antibody for 2 h at room temperatu... View More
Product Details
703928
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
18H31L38
Immunogen
Peptides corresponding to human GRPR [aa364-aa384, aa4-aa19]
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
This antibody is predicted to react with Mouse, Rat, Bovine.
Target Information
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bombesin receptor 2; Gastrin-releasing peptide receptor; GRP receptor; GRP-preferring bombesin receptor; GRP-R; unnamed protein product
Gene Aliases: BB2; BB2R; BRS2; GRPR
UniProt ID: (Human) P30550
Entrez Gene ID: (Human) 2925
signal transduction
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
learning or memory
social behavior
psychomotor behavior
regulation of cell proliferation
response to external biotic stimulus
motor behavior
positive regulation of respiratory gaseous exchange
positive regulation of behavioral fear response
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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