Search
Additional Information:
{{banner.description}}
FIGURE: 1 / 5
Pannexin 1 Antibody (710184) in ICC/IF
Immunofluorescent analysis of Pannexin-1 in HEK293 cells using a Pannexin-1 Recombinant Rabbit Superclonal™ Antibody (Product # 710184) followed by detection using an Alexa Fluor 488-conjugated Goat anti-Rabbit secondary antibody (green) (Image A). b: Image of DAPI stained nucleus (blue) and Alexa Fluor 594 phalloidin stained actin (red) c: Composite image of cells showing cell-membrane and junction localiz... View More
Product Details
710184
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Superclonal
Type
Antibody
Clone
11HCLC
Immunogen
Peptide corresponding to amino acids 347-360 of human pannexin 1
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.
Target Information
The pannexin gene family encodes a second class of putative gap junction proteins and are highly conserved in invertebrates and mammals. Pannexins (Panx) are four-pass transmembrane proteins that oligomerize to form large pore ion and metabolite-permeable channels. Pannexin-1 (PANX1) and Pannexin-3 are closely related, while Pannexin-2 is a more distant relation. PANX1 is a transmembrane protein that forms a mechanosensitive ATP-permeable channel between adjacent cells and in the endoplasmic reticulum. PANX1 may play a role as a Ca2+ -leak channel to regulate ER Ca2+ homeostasis and regulates neural stem and progenitor cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: innexin; Pannexin-1; PANX1; unnamed protein product
Gene Aliases: MRS1; OOMD7; OZEMA7; PANX1; PX1; UNQ2529; UNQ2529/PRO6028
UniProt ID: (Human) Q96RD7
Entrez Gene ID: (Human) 24145
protease binding
actin binding
receptor binding
structural molecule activity
gap junction channel activity
anion channel activity
calcium channel activity
ATP transmembrane transporter activity
protein binding
channel activity
wide pore channel activity
leak channel activity
identical protein binding
ion channel binding
macromolecular complex binding
actin filament binding
gap junction hemi-channel activity
scaffold protein binding
response to ischemia
ion transport
cation transport
calcium ion transport
cell-cell signaling
ATP transport
cell differentiation
positive regulation of interleukin-1 alpha production
positive regulation of interleukin-1 beta production
positive regulation of interleukin-1 production
response to ATP
ion transmembrane transport
oogenesis
positive regulation of macrophage cytokine production
calcium ion transmembrane transport
anion transmembrane transport
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support