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Invitrogen

WNT4 Recombinant Superclonal™ Antibody (9HCLC)

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WNT4 Recombinant Superclonal™ Antibody (9HCLC)

Product Details

710889

Applications
Tested Dilution
Publications

Western Blot (WB)

0.5-1 µg/mL
-

Immunocytochemistry (ICC/IF)

0.5 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Superclonal

Type

Antibody

Clone

9HCLC

Immunogen

Multiple peptides corresponding to Human Wnt4 (aa 58-71; 235-253; 258-269)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2532778

Product Specific Information

This antibody is predicted to react with Monkey, Pig, Rat and Mouse.

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.

Target Information

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Protein Wnt-4; unnamed protein product; wingless-type MMTV integration site family, member 4

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Gene Aliases: SERKAL; UNQ426/PRO864; WNT-4; WNT4

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UniProt ID: (Human) P56705

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Entrez Gene ID: (Human) 54361

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Function(s)
transcription corepressor activity receptor binding frizzled binding cytokine activity receptor agonist activity
Process(es)
metanephros development branching involved in ureteric bud morphogenesis kidney development mesonephros development epithelial to mesenchymal transition embryonic epithelial tube formation liver development gamete generation sex differentiation fibroblast growth factor receptor signaling pathway male gonad development female gonad development cellular response to starvation negative regulation of gene expression negative regulation of steroid biosynthetic process Wnt signaling pathway regulation of cell-cell adhesion cell differentiation neuron differentiation female sex determination adrenal gland development negative regulation of cell migration positive regulation of bone mineralization positive regulation of aldosterone biosynthetic process positive regulation of collagen biosynthetic process T cell differentiation in thymus immature T cell proliferation in thymus tube morphogenesis non-canonical Wnt signaling pathway negative regulation of fibroblast growth factor receptor signaling pathway hormone metabolic process positive regulation of MAPK cascade cell fate commitment negative regulation of cell differentiation positive regulation of osteoblast differentiation positive regulation of meiotic nuclear division negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of Ras protein signal transduction oocyte development branching morphogenesis of an epithelial tube smooth muscle cell differentiation positive regulation of stress fiber assembly positive regulation of focal adhesion assembly Sertoli cell differentiation canonical Wnt signaling pathway somatotropin secreting cell differentiation thyroid-stimulating hormone-secreting cell differentiation mesenchymal to epithelial transition tertiary branching involved in mammary gland duct morphogenesis kidney morphogenesis negative regulation of wound healing mammary gland epithelium development positive regulation of dermatome development paramesonephric duct development negative regulation of testicular blood vessel morphogenesis cellular response to transforming growth factor beta stimulus nephron development renal vesicle formation renal vesicle induction metanephric mesenchymal cell differentiation mesonephric tubule development metanephric tubule formation metanephric nephron development metanephric nephron morphogenesis apoptotic signaling pathway meiotic nuclear division pericyte cell differentiation negative regulation of male gonad development positive regulation of cortisol biosynthetic process negative regulation of androgen biosynthetic process negative regulation of testosterone biosynthetic process negative regulation of apoptotic signaling pathway
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