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Invitrogen

c-Jun Recombinant Superclonal™ Antibody (2HCLC)

Advanced Verification
2 Published Figures
4 References
View all (147) c-Jun antibodies

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c-Jun Recombinant Superclonal™ Antibody (2HCLC)

Product Details

711202

Applications
Tested Dilution
Publications

Western Blot (WB)

1:250-1:2,500
View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

2 µg/mL
-

Flow Cytometry (Flow)

-
View 1 publication 1 publication

ChIP assay (ChIP)

2.5 µg x 10^6 cells
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Superclonal

Type

Antibody

Clone

2HCLC

Immunogen

Peptides corresponding to Human JUN (aa 21-36, 211-228)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2633131

Product Specific Information

This antibody is predicted to react with Monkey, Bovine, Pig and Mouse.

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.

Target Information

c-Jun is a transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. It promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Activator protein 1; AH119; AP1; cjun; enhancer-binding protein AP1; immediate early; JUN; Jun A; Jun activation domain binding protein; Jun oncogene; JUND; p39; Proto-oncogene c-Jun; proto-oncogene cJun; transcription factor AP-1; Transcription factor AP-1 subunit Jun; Transcription factor Jun; V-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog

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Gene Aliases: AP-1; AP1; c-Jun; cJUN; JUN; Junc; p39

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UniProt ID: (Human) P05412, (Mouse) P05627

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Entrez Gene ID: (Human) 3725, (Mouse) 16476

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding RNA binding GTPase activator activity protein binding enzyme binding ubiquitin protein ligase binding cAMP response element binding identical protein binding ubiquitin-like protein ligase binding RNA polymerase II sequence-specific DNA binding transcription factor binding R-SMAD binding general transcription initiation factor binding sequence-specific double-stranded DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II activating transcription factor binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription coactivator activity transcription factor binding protein homodimerization activity sequence-specific DNA binding transcription regulatory region DNA binding poly(A) RNA binding protein heterodimerization activity HMG box domain binding basic leucine zipper transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter angiogenesis microglial cell activation liver development positive regulation of endothelial cell proliferation outflow tract morphogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter apoptotic process transforming growth factor beta receptor signaling pathway JNK cascade cell proliferation negative regulation of cell proliferation response to xenobiotic stimulus positive regulation of epithelial cell migration release from viral latency monocyte differentiation axon regeneration response to endoplasmic reticulum stress leading edge cell differentiation response to muscle stretch regulation of cell proliferation positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of DNA binding negative regulation of neuron apoptotic process negative regulation by host of viral transcription positive regulation by host of viral transcription negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of fibroblast proliferation response to steroid hormone regulation of cell cycle SMAD protein signal transduction eyelid development in camera-type eye positive regulation of ERK1 and ERK2 cascade cellular response to calcium ion cellular response to anisomycin integrated stress response signaling positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of vascular smooth muscle cell proliferation positive regulation of DNA-templated transcription, initiation release of cytochrome c from mitochondria transcription, DNA-templated transcription from RNA polymerase II promoter SMAD protein import into nucleus learning positive regulation of cell proliferation response to radiation cellular process negative regulation of protein autophosphorylation response to lipopolysaccharide cellular response to hormone stimulus response to cytokine response to drug positive regulation of neuron apoptotic process positive regulation of GTPase activity positive regulation of cell differentiation positive regulation of monocyte differentiation positive regulation of DNA replication positive regulation of smooth muscle cell proliferation cellular response to potassium ion starvation response to cAMP membrane depolarization negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
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