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NeoBiotechnologies
Vimentin (Mesenchymal Cell Marker) Monoclonal Antibody (VM452), CF® 488
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Product Details
7431-MSM1-CF488-100T
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Chicken,
Cat,
Goat,
Human,
Pig
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
VM452
Immunogen
Recombinant human vimentin protein
Conjugate
Excitation/Emission Max
488/515 nm
Form
Liquid
Concentration
100 µg/mL
Amount
50 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Does not react with Mouse or Rat
Target Information
Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Unlike other IFP proteins, vimentin is expressed, along with desmin, during the early stages of cellular development. During the development process, vimentin is exchanged for new, tissue-specific IFPs. Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. This results in cytoskeletal changes that facilitate the interaction of the lipid droplets within mitochondria, and subsequent transport of cholesterol to the organelles leading to an increase in steroid synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein; FLJ36605; Hel113; intermediate filament protein; RP11-124N14.1; unnamed protein product; VIM; VIME; Vimentin; vimentin C-terminus
Gene Aliases: VIM
UniProt ID: (Pig) P02543, (Bovine) P48616, (Human) P08670, (Dog) A0A8C0N8E3
Entrez Gene ID: (Pig) 100522394, (Bovine) 280955, (Chicken) 420519, (Human) 7431, (Dog) 477991, (Goat) 102182515
negative regulation of neuron projection development
astrocyte development
positive regulation of collagen biosynthetic process
regulation of mRNA stability
intermediate filament organization
positive regulation of translation
Bergmann glial cell differentiation
SMAD protein signal transduction
lens fiber cell development
cellular response to lipopolysaccharide
cellular response to muramyl dipeptide
cellular response to interferon-gamma
in utero embryonic development
positive regulation of superoxide anion generation
positive regulation of gene expression
neuron projection development
intermediate filament-based process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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