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Antibodies Inc
Kv1.1 K+ Channel Monoclonal Antibody (K20/78), FL490
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Product Details
75-007-FL490
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Avian,
Human,
Mouse,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
K20/78
Immunogen
Synthetic peptide amino acids 458-476 (cytoplasmic C-terminus) of rat Kv1.1 (EEDMNNSIAHYRQANIRTG; accession number P10499).
Conjugate
FL490
FL490
FL490
Excitation/Emission Max
491/515 nm
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments, and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif. The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brain potassium channel protein-1; IA; megencephaly; MGC126782; MGC138385; MKI; potassium (K+) channel protein voltage dependent; potassium channel, voltage gated shaker related subfamily A, member 1; potassium voltage gated channel shaker related subfamily member 1; potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia); RBKI; RCK1; unnamed protein product; voltage-gated K(+) channel HuKI; voltage-gated potassium channel; voltage-gated potassium channel HBK1; voltage-gated potassium channel subunit Kv1.1
Gene Aliases: AEMK; EA1; HBK1; HUK1; Kca1-1; Kcna; Kcpvd; KV1.1; MBK1; mceph; Mk-1; MK1; RBK1; Shak
UniProt ID: (Human) Q09470, (Mouse) P16388, (Rat) P10499
Entrez Gene ID: (Human) 3736, (Rabbit) 100037722, (Mouse) 16485, (Rat) 24520
ion channel activity
voltage-gated potassium channel activity
delayed rectifier potassium channel activity
protein binding
disordered domain specific binding
voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
voltage-gated ion channel
action potential
startle response
ion transport
potassium ion transport
regulation of muscle contraction
neuroblast proliferation
brain development
cell communication by electrical coupling
magnesium ion homeostasis
neuronal action potential
hippocampus development
neuronal signal transduction
regulation of membrane potential
neuromuscular process
detection of mechanical stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of touch
protein homooligomerization
transmembrane transport
cellular response to magnesium ion
potassium ion transmembrane transport
membrane repolarization during action potential
protein localization
regulation of postsynaptic membrane potential
regulation of presynaptic membrane potential
positive regulation of voltage-gated potassium channel activity
optic nerve development
cerebral cortex development
corpus callosum development
axon development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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