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KCC2 Monoclonal Antibody (N1/12)
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FIGURE: 1 / 5
KCC2 Antibody (75-013) in ICC/IF
HEK-293 cells were transiently transfected with rnKCC2bWT or rnKCC2 variants with mutations in the chloride-binding site 1. Immunocytochemistry was used to monitor the transfection rate of the rnKCC2 variants (Product # 75-013, 1:1000; green) and cell staining by DAPI (blue). Image from publication CC-BY-4.0. PMID:37625593.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
75-013
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat,
Zebrafish
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
N1/12
Immunogen
Fusion protein amino acids 932-1043 (intracellular carboxyl terminus) of rat KCC2 (accession number Q63633) produced recombinantly in E. Coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4
Contains
0.065% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: electroneutral K-dependent Cl cotransporter-2; electroneutral potassium-chloride cotransporter 2; erythroid K-Cl cotransporter 2; furosemide-sensitive K-Cl cotransporter; K-Cl cotransporter 2; KCC 2; KCC2a; mKCC2; neuronal K-Cl cotransporter; neuronal-specific K-Cl cotransporter; S12A5; solute carrier family 12 (potassium-chloride transporter), member 5; solute carrier family 12 (potassium/chloride transporter), member 5; unnamed protein product
Gene Aliases: DEE34; EIEE34; EIG14; hKCC2; KCC2; mKIAA1176
UniProt ID: (Human) Q9H2X9, (Rat) Q63633, (Mouse) Q91V14
Entrez Gene ID: (Human) 57468, (Rat) 171373, (Mouse) 57138
ion transport
potassium ion transport
chloride transport
hypotonic response
chemical synaptic transmission
learning
response to xenobiotic stimulus
cellular chloride ion homeostasis
developmental process
multicellular organism growth
thermosensory behavior
intracellular pH reduction
transmembrane transport
dendritic spine development
potassium ion transmembrane transport
ammonium transmembrane transport
postsynaptic neurotransmitter receptor diffusion trapping
regulation of postsynapse assembly
chloride transmembrane transport
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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