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Kv2.2 K+ Channel Monoclonal Antibody (K37/89), FL490
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Product Details
75-015-FL490
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
K37/89
Immunogen
Fusion protein amino acids 1-61 of rat Kv2.2 (accession number Q63099) produced recombinantly in E. Coli.
Conjugate
Excitation/Emission Max
491/515 nm
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
Kcnb2 (Kv2.2) encodes a Voltage-gated K+ channel which are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variation in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. The delayed rectifier-type (IK) channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites and are also found in a wide variety on non-neuronal cell types including pancreatic islet, alveolar cells and cardiac myocytes. Kv2.1 and Kcnb2 form distinct populations of K+ channels and these subunits are thought to be primarily responsible for IK in superior cervical ganglion cells. Functionally, Kcnb2 mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Diseases associated with KCNB2 include Brugada Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDRK; delayed rectifier potassium channel protein; potassium channel Kv2.2; potassium channel, voltage gated Shab related subfamily B, member 2; potassium voltage gated channel, Shab-related subfamily, member 2; Potassium voltage-gated channel subfamily B member 2; potassium voltage-gated channel, Shab-related subfamily, member 2; voltage-gated potassium channel alpha subunit Kv2.2; Voltage-gated potassium channel subunit Kv2.2
Gene Aliases: 9630047L19Rik; BB130875; KCNB2; KV2.2
UniProt ID: (Human) Q92953, (Rabbit) Q95L11, (Mouse) A6H8H5
Entrez Gene ID: (Human) 9312, (Rabbit) 100008877, (Mouse) 98741, (Rat) 117105
ion channel activity
voltage-gated potassium channel activity
delayed rectifier potassium channel activity
potassium channel activity
protein binding
potassium channel regulator activity
protein heterodimerization activity
voltage-gated ion channel activity
ion channel binding
voltage-gated ion channel
action potential
ion transport
potassium ion transport
regulation of smooth muscle contraction
ion transmembrane transport
protein homooligomerization
transmembrane transport
potassium ion transmembrane transport
protein localization to plasma membrane
transport
regulation of ion transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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