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Kv4.3 K+ Channel Monoclonal Antibody (K75/41), FL650
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Product Details
75-017-FL650
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fruit fly,
Guinea pig,
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
K75/41
Immunogen
Fusion protein amino acids 415-636 (cytoplasmic C- terminus) of rat Kv4.3 (accession number Q62897) produced recombinantly in E. Coli.
Conjugate
Excitation/Emission Max
655/676 nm
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A-type voltage-gated potassium channel KCND3; long splice variant; potassium channel Kv4.3L; potassium channel Kv4.3M; potassium channel, voltage gated Shal related subfamily D, member 3; potassium ionic channel Kv4.3; potassium voltage gated channel, Shal-related family, member 3; potassium voltage-gated channel long; Potassium voltage-gated channel subfamily D member 3; potassium voltage-gated channel, Shal-related subfamily, member 3; sha1-related potassium channel Kv4.3; shal-related family member 3; similar to cardiac ITO1; voltage-gated K+ channel; Voltage-gated potassium channel subunit Kv4.3
Gene Aliases: AW045978; BRGDA9; KCND3; KCND3L; KCND3S; Kncd3; KSHIVB; KV4.3; SCA19; SCA22
UniProt ID: (Human) Q9UK17, (Mouse) Q9Z0V1, (Rat) Q62897
Entrez Gene ID: (Human) 3752, (Mouse) 56543, (Rat) 65195
ion channel activity
voltage-gated potassium channel activity
A-type (transient outward) potassium channel activity
potassium channel activity
protein binding
metal ion binding
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
voltage-gated ion channel activity
ion channel binding
delayed rectifier potassium channel activity
voltage-gated ion channel
action potential
ion transport
potassium ion transport
muscle contraction
chemical synaptic transmission
regulation of heart contraction
ion transmembrane transport
protein homooligomerization
protein tetramerization
transmembrane transport
potassium ion transmembrane transport
membrane repolarization
membrane repolarization during cardiac muscle cell action potential
regulation of heart rate by cardiac conduction
potassium ion export across plasma membrane
membrane repolarization during ventricular cardiac muscle cell action potential
ventricular cardiac muscle cell membrane repolarization
transport
regulation of ion transmembrane transport
potassium ion export
cellular response to BMP stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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