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Pan-Neurofascin Monoclonal Antibody (L11A/41)
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Product Details
75-027
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
L11A/41
Immunogen
Fusion protein 1066-1174 (intracellular domain common to NF-155 and NF-186) of rat NF-155 (accession number AAL27854) produced recombinantly in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4
Contains
0.065% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
Neurofascin encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. Neurofascin undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp686P2250; KIAA0756FLJ46866; Neurofascin; neurofascin homolog; unnamed protein product
Gene Aliases: KIAA0756; NEDCPMD; NF; NFASC; NRCAML
UniProt ID: (Human) O94856, (Rat) P97685
Entrez Gene ID: (Human) 23114, (Rat) 116690
cell adhesion
axon guidance
brain development
peripheral nervous system development
myelination
cell-cell adhesion
protein localization to paranode region of axon
transmission of nerve impulse
paranodal junction assembly
heterotypic cell-cell adhesion
clustering of voltage-gated sodium channels
synapse organization
protein localization to juxtaparanode region of axon
protein targeting to plasma membrane
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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