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PSD-95 Monoclonal Antibody (K28/43), FL490
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Product Details
75-028-FL490
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken,
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
K28/43
Immunogen
Fusion protein amino acids 77-299 (PDZ domains 1 and 2) of human PSD-95 (accession number P78352) produced recombinantly in E. Coli.
Conjugate
FL490
FL490
FL490
Excitation/Emission Max
491/515 nm
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
Post Synaptic Density 95 kDa (PSD-95), also known as synapse associated protein 90 kDa (SAP90), is one of a family of membrane-associated proteins found in the postsynaptic density in forebrain neurons and certain presynaptic structures in the cerebellum. Like other members of the family, PSD-95 has three 90 amino acid repeats called PDZ domains followed by an SH3 domain and a yeast guanylate kinase homology (GuK) domain. PSD-95 is believed to participate in the clustering of certain proteins, including NMDA receptors, Shaker-type potassium channels at the synaptic membrane in central nervous system (CNS) neurons. There are two principal modes of interaction between PSD-95 and other proteins. NMDA receptors and shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits), and some of these proteins may interact with PSD-95 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with PSD-95 in vitro through a pseudo-homotypic PDZ-PDZ interaction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: discs large homolog 4; discs, large homolog 4; FLJ97752; FLJ98574; post synaptic density; post-synaptic density protein 95; postsynaptic density protein 95; PSD-95; PSD-95 alpha 2b; PSD-95 beta; SAP-90; synapse-associated protein 90; synapse-associated protein SAP90; Tax interaction protein 15; unnamed protein product
Gene Aliases: Dlgh4; MRD62; PSD-95; PSD95; SAP-90; SAP90; SAP90A
UniProt ID: (Human) P78352, (Rat) P31016, (Mouse) Q62108
Entrez Gene ID: (Human) 1742, (Rat) 29495, (Mouse) 13385
protein binding
kinase binding
protein kinase binding
protein phosphatase binding
GKAP/Homer scaffold activity
PDZ domain binding
protein binding, bridging
beta-1 adrenergic receptor binding
D1 dopamine receptor binding
P2Y1 nucleotide receptor binding
acetylcholine receptor binding
ionotropic glutamate receptor binding
macromolecular complex binding
neuroligin family protein binding
scaffold protein binding
receptor binding
frizzled binding
kinesin binding
beta-2 adrenergic receptor binding
glutamate receptor binding
structural constituent of postsynaptic density
structural molecule activity
neurexin family protein binding
negative regulation of receptor internalization
positive regulation of cytosolic calcium ion concentration
chemical synaptic transmission
nervous system development
synaptic vesicle maturation
developmental maturation
cerebral cortex development
social behavior
protein localization to synapse
locomotory exploration behavior
cellular response to potassium ion
neuronal ion channel clustering
establishment of protein localization
regulation of neuronal synaptic plasticity
regulation of long-term neuronal synaptic plasticity
positive regulation of dendrite morphogenesis
positive regulation of synaptic transmission
neuromuscular process controlling balance
positive regulation of synapse assembly
dendritic spine morphogenesis
protein-containing complex assembly
vocalization behavior
protein localization to membrane
dendritic spine organization
AMPA glutamate receptor clustering
receptor localization to synapse
cell-cell adhesion
NMDA selective glutamate receptor signaling pathway
regulation of postsynaptic membrane neurotransmitter receptor levels
maintenance of postsynaptic density structure
neurotransmitter receptor localization to postsynaptic specialization membrane
positive regulation of neuron projection arborization
positive regulation of AMPA glutamate receptor clustering
regulation of N-methyl-D-aspartate selective glutamate receptor activity
positive regulation of excitatory postsynaptic potential
regulation of grooming behavior
locomotory behavior
response to cocaine
signal transduction
learning
establishment or maintenance of epithelial cell apical/basal polarity
long term synaptic depression
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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