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Antibodies Inc
Pancortin Monoclonal Antibody (K96/7), FL490
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Product Details
75-042-FL490
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
K96/7
Immunogen
Synthetic peptide of amino acids 131-150 of human Pancortin (GLESKFKQVEE SHKQHLARQ, accession number Q99784).
Conjugate
Excitation/Emission Max
491/515 nm
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
The Olfactomedin family comprises a diverse group of secreted glycoproteins, which includes OLFM1 (Noelin-1), OLFM2 (Noelin-2), OLFM3 (Noelin-3), OLFM4 (Noelin-4), tiarin, pancortin, gliomedin and mycocilin. These proteins are implicated in the development of the nervous system. Specifically, OLFM1 and OLFM2 expression is observed in the neural plate and neural crest, as well as in the cranial ganglia in mouse at E8-10, and later in brain tissue and in the zone of polarizing activity in the limb. Overexpression of OLFM1 causes an excess of neural crest emigrations and prolonged neural crest production. OLFM2 participates in the regulation of the development of the anterior nervous system. An Arg144Gln mutation in OLFM2 has been implicated as a possible cause for open-angle glaucoma (OAG).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 1B426B; neuroblastoma protein; Neuronal olfactomedin-related ER localized protein; Noelin; Noelin 1; Noelin 2; olfactomedin related ER localized protein; Olfactomedin-1; Pancortin; pancortin 1; Pancortin 1-4; unnamed protein product
Gene Aliases: AMY; AW742568; D2Sut1e; NOE1; Noel; NOEL1; NOELIN1; OlfA; OLFM1; Pancortin; Pancortin3
UniProt ID: (Human) Q99784, (Mouse) O88998, (Rat) Q62609
Entrez Gene ID: (Human) 10439, (Mouse) 56177, (Rat) 93667
atrioventricular valve formation
signal transduction
nervous system development
positive regulation of gene expression
negative regulation of gene expression
positive regulation of epithelial to mesenchymal transition
neuronal signal transduction
regulation of axon extension
positive regulation of apoptotic process
cardiac epithelial to mesenchymal transition
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
multicellular organism development
protein oligomerization
regulation of beta-amyloid formation
negative regulation of beta-amyloid formation
negative regulation of neuron migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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