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Antibodies Inc
Shank1 Monoclonal Antibody (N22/21), FL490
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Product Details
75-064-FL490
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N22/21
Immunogen
Fusion protein amino acids 469-691 (SH3/PDZ domains) of rat Shank1 (accession number Q9WV48) produced recombinantly in E. Coli.
Conjugate
Excitation/Emission Max
491/515 nm
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GKAP/SAPAP interacting protein; GKAP/SAPAP-interacting protein; multidomain postsynaptic density protein; OTTHUMP00000174437; postsynaptic scaffold protein; SAPAP-interacting protein synamon; SH3 and multiple ankyrin repeat domains 1; SH3 and multiple ankyrin repeat domains protein 1; SH3/ankyrin domain gene 1; SHANK 1; Shank1; Somatostatin receptor-interacting protein; SPANK 1; SPANK-1; SSTR-interacting protein; Synamon
Gene Aliases: SHANK1; Shank1a; SPANK-1; Spank1; SSTRIP; synamon
UniProt ID: (Human) Q9Y566, (Rat) Q9WV48, (Mouse) D3YZU1
Entrez Gene ID: (Human) 50944, (Rat) 78957, (Mouse) 243961
G-protein coupled receptor binding
protein binding
SH3 domain binding
receptor signaling complex scaffold activity
GKAP/Homer scaffold activity
somatostatin receptor binding
ionotropic glutamate receptor binding
identical protein binding
macromolecular complex binding
ankyrin repeat binding
scaffold protein binding
structural constituent of postsynaptic density
protein C-terminus binding
protein complex binding
nervous system development
long-term memory
associative learning
cell differentiation
adult behavior
negative regulation of actin filament bundle assembly
social behavior
protein localization to synapse
olfactory behavior
habituation
modulation of synaptic transmission
synapse organization
neuromuscular process controlling balance
cognition
determination of affect
righting reflex
synapse maturation
dendritic spine morphogenesis
positive regulation of dendritic spine development
protein-containing complex assembly
vocalization behavior
AMPA selective glutamate receptor signaling pathway
maintenance of postsynaptic density structure
positive regulation of excitatory postsynaptic potential
protein complex assembly
cytoskeletal anchoring at plasma membrane
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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