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Antibodies Inc
CASPR2 Monoclonal Antibody (K67/25)
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Product Details
75-075
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
K67/25
Immunogen
Fusion protein 96-1265 (extracellular domain) of human Caspr2 (accession number A0A090N7T7) produced recombinantly in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4
Contains
0.065% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cell recognition molecule Caspr2; contactin associated protein like 2; contactin associated protein-like 2; Contactin-associated protein-like 2; DKFZp781D1846; homolog of Drosophila neurexin IV; unnamed protein product
Gene Aliases: 5430425M22Rik; AUTS15; CASPR2; CDFE; CNTNAP2; KIAA0868; mKIAA0868; NRXN4; PTHSL1
UniProt ID: (Human) Q9UHC6, (Mouse) Q9CPW0
Entrez Gene ID: (Human) 26047, (Rat) 500105, (Mouse) 66797
startle response
cell adhesion
central nervous system development
brain development
learning
neuron recognition
cell proliferation
transmission of nerve impulse
striatum development
limbic system development
thalamus development
cerebral cortex development
adult behavior
neuron projection development
social behavior
vocal learning
clustering of voltage-gated potassium channels
neuron projection morphogenesis
prepulse inhibition
superior temporal gyrus development
protein localization to juxtaparanode region of axon
vocalization behavior
positive regulation of gap junction assembly
cellular protein localization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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