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Antibodies Inc
SynCAM1 Monoclonal Antibody (L45/30)
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Product Details
75-120
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
L45/30
Immunogen
Fusion protein amino acids 257-388 of mouse SynCAM1 (accession number Q8R5M8), recognizes 1.4b isoform only (epitope narrowed to GLTQLPNSAEELDSEDLS) produced recombinantly in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4
Contains
0.065% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
Mediates homophilic cell-cell adhesion in a Ca (2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca (2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cadm1; Cell adhesion molecule 1; cell adhesion molecule 1 transcript variant 8abc; IGSF4; Immunoglobulin superfamily member 4; immunoglobulin superfamily member 4A; immunoglobulin superfamily membrane protein; immunoglobulin superfamily, member 4A; immunosuperfamily protein Bl2; NECL-2; nectin-like 2; Nectin-like protein 2; secretory isoform of TSLC1; SgIgSF; Spermatogenic immunoglobulin superfamily; Synaptic cell adhesion molecule; SynCAM; TSLC-1; TSLC1/Nectin-like 2/IGSF4; tumor suppressor; Tumor suppressor in lung cancer 1; Tumor suppressor in lung cancer 1 homolog; unnamed protein product
Gene Aliases: 2900073G06Rik; 3100001I08Rik; AI987920; BL2; CADM1; IGSF4; IGSF4A; Necl-2; NECL2; RA175; RA175A; RA175B; RA175C; RA175N; SgIGSF; ST17; sTSLC-1; SYNCAM; SynCam1; TSLC1
UniProt ID: (Human) Q9BY67, (Mouse) Q8R5M8, (Rat) Q6AYP5
Entrez Gene ID: (Human) 23705, (Mouse) 54725, (Rat) 363058
positive regulation of cytokine production
T cell mediated cytotoxicity
immune system process
apoptotic process
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
spermatogenesis
cell recognition
cell differentiation
susceptibility to natural killer cell mediated cytotoxicity
positive regulation of natural killer cell mediated cytotoxicity
activated T cell proliferation
detection of stimulus
liver development
multicellular organism development
synapse assembly
unidimensional cell growth
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
positive regulation of cytokine secretion
bone development
brain development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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