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Ankyrin-G Monoclonal Antibody (N106/65)
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FIGURE: 1 / 2
Ankyrin-G Antibody (75-147) in IHC (F)
Representative images showed the high expression level of FKBP12 (green) in axonal hillock/axon initial segment (labeled by anti–ankyrin-G antibody, cat. 75-147; bright blue) under basal conditions whereas FKBP12 translocated to soma and dendrites when neurons bear tau aggregation. Image from publication CC-BY-4.0. PMID:36724228.
Product Details
75-147
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
N106/65
Immunogen
Fusion protein ~1000 amino acids of Ankyrin-G (accession number E9PE32) produced recombinantly in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4
Contains
0.065% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
Ankyrin-G is found in several tissues including brain where, due to tissue-specific RNA processing, it is expressed as two different isoforms, localized to axon initial segments and nodes of Ranvier. Ankyrin-G is also found at sites of epithelial cell-cell contact and in the intracellular membranes of some cells. Ankyrin-G isoforms contain a unique stretch of sequence highly enriched in serine and threonine residues immediately following a globular head domain. Ankyrin-G is thought to participate in the maintenance and targeting of ion channels and cell adhesion molecules to the nodes of Ranvier and to axon initial segments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ANK-3; ankyrin 3 (G); ankyrin 3, epithelial; ankyrin 3, node of Ranvier (ankyrin G); Ankyrin-3; Ankyrin-G; brain-specific ankyrin-G; unnamed protein product
Gene Aliases: 2900054D09Rik; AI314020; ANK-3; ANK3; AnkG; Ankyrin-3; ANKYRIN-G; MRT37
UniProt ID: (Human) Q12955, (Rat) O70511, (Mouse) G5E8K5
Entrez Gene ID: (Human) 288, (Rat) 361833, (Mouse) 11735
mitotic cytokinesis
plasma membrane organization
cytoskeleton organization
signal transduction
axonogenesis
neuromuscular junction development
positive regulation of gene expression
positive regulation of cell communication by electrical coupling
positive regulation of sodium ion transport
magnesium ion homeostasis
neuronal action potential
positive regulation of homotypic cell-cell adhesion
Golgi to plasma membrane protein transport
regulation of potassium ion transport
establishment of protein localization
positive regulation of membrane potential
Golgi vesicle transport
cellular response to magnesium ion
membrane assembly
protein localization to plasma membrane
maintenance of protein location in plasma membrane
positive regulation of protein targeting to membrane
protein localization to axon
positive regulation of membrane depolarization during cardiac muscle cell action potential
negative regulation of delayed rectifier potassium channel activity
axon guidance
synapse organization
protein targeting to plasma membrane
positive regulation of sodium ion transmembrane transporter activity
positive regulation of cation channel activity
positive regulation of action potential
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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