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Antibodies Inc
Nav1.8 Na+ Channel Monoclonal Antibody (N134/12), FL550
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Product Details
75-166-FL550
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
N134/12
Immunogen
Fusion protein amino acids 1724-1956 (cytoplasmic C-terminus) of rat Nav1.8 (accession number Q62968) produced recombinantly in E. Coli.
Conjugate
Excitation/Emission Max
550/575 nm
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
Scn10a is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Scn10a mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, Scn10a forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Scn10a also plays a role in neuropathic pain mechanisms. Structurally, members of Deg/ENaC superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddels syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1). Diseases associated with SCN10A include Episodic Pain Syndrome, Familial, 2 and Sodium Channelopathy-Related Small Fiber Neuropathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: mPN3; Peripheral nerve sodium channel 3; PN3; SCN10A/PN3; Sensory neuron sodium channel; Sodium channel protein type 10 subunit alpha; Sodium channel protein type X subunit alpha; sodium channel type X alpha polypeptide; sodium channel voltage-gated type X alpha polypeptide; sodium channel, voltage-gated, type 10, alpha polypeptide; sodium channel, voltage-gated, type X, alpha polypeptide; sodium channel, voltage-gated, type X, alpha subunit; voltage gated sodium channel; Voltage-gated sodium channel subunit alpha Nav1.8
Gene Aliases: FEPS2; Na(V)1.8; Nav1.8; PN3; SCN10A; SNS
UniProt ID: (Human) Q9Y5Y9, (Rat) Q62968, (Mouse) Q6QIY3
Entrez Gene ID: (Human) 6336, (Rat) 29571, (Mouse) 20264
ion channel activity
voltage-gated sodium channel activity
cation channel activity
sodium channel activity
ion channel binding
voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
protein binding
voltage-gated ion channel activity
voltage-gated ion channel
regulation of heart rate
ion transport
sodium ion transport
sensory perception
ion transmembrane transport
regulation of ion transmembrane transport
sodium ion transmembrane transport
odontogenesis of dentin-containing tooth
transmembrane transport
regulation of cardiac muscle contraction
regulation of atrial cardiac muscle cell membrane depolarization
cardiac muscle cell action potential involved in contraction
membrane depolarization during action potential
AV node cell action potential
bundle of His cell action potential
regulation of presynaptic membrane potential
neuronal action potential
sensory perception of pain
cardiac conduction
AV node cell to bundle of His cell communication
bundle of His cell to Purkinje myocyte communication
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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