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Pan-PTPR (Receptor-Type Tyrosine-Protein Phosphatase) Monoclonal Antibody (N165/43)

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Pan-PTPR (Receptor-Type Tyrosine-Protein Phosphatase) Monoclonal Antibody (N165/43)

Product Details

75-194

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

N165/43

Immunogen

Fusion protein amino acids 1315-1607 (cytoplasmic C-terminus) of human LAR (accession number P10586) produced recombinantly in E. Coli.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4

Contains

0.065% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Dry ice (international)

Product Specific Information

For maximum recovery of product, centrifuge the vial prior to removing the cap.

Target Information

Pan-PTPR refers to the collective group of Protein Tyrosine Phosphatase Receptor (PTPR) family members, which are enzymes that dephosphorylate tyrosine residues on proteins. These receptors play key roles in regulating a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Their dysregulation is often associated with various diseases, including cancer and autoimmune disorders.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: LAR; LAR-PTP2; LCA-homolog; leukocyte antigen-related (LAR) PTP receptor; leukocyte antigen-related tyrosine phosphatase; Leukocyte common antigen related; Leukocyte common antigen-related protein-tyrosine phosphatase 2; leukocyte common antigen-related proten-tyrosine phosphatase 2; protein tyrosine phosphatase PTPsigma; protein tyrosine phosphatase receptor-type F; protein tyrosine phosphatase, receptor type, D; protein tyrosine phosphatase, receptor type, delta polypeptide; protein tyrosine phosphatase, receptor type, F polypeptide; Protein-tyrosine phosphatase delta; PTPNU-3; R-PTP-S; R-PTP-sigma; rceptor-type tyrosine-protein phosphatase delta; receptor-linked protein-tyrosine phosphatase LAR; Receptor-type tyrosine-protein phosphatase delta; Receptor-type tyrosine-protein phosphatase F; Receptor-type tyrosine-protein phosphatase S; Receptor-type tyrosine-protein phosphatase sigma; tissue-specific protein tyrosine phosphatase; unnamed protein product

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Gene Aliases: 1110002J03Rik; 3000002J10Rik; AA591035; AL022616; B230219D21Rik; BNAH2; HPTP; HPTPD; HPTPDELTA; LAR; LARFN5C; Larptp2; LARS; PTP; PTP-NU3; PTP-sigma; PTPD; PTPNU-3; PTPRD; PTPRF; PTPRS; PTPSIGMA; Ptpsigma.; Ptpt9; R-PTP-delta; R-PTP-S; R-PTP-sigma; RPTP-LAR; Rptpd; RPTPDELTA; RPTPsigma

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UniProt ID: (Human) P23468, (Human) P10586, (Human) Q13332, (Mouse) Q64487, (Rat) Q64604, (Mouse) A2A8L5, (Mouse) B0V2N1, (Rat) Q64605

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Entrez Gene ID: (Human) 5789, (Human) 5792, (Human) 5802, (Mouse) 19266, (Rat) 313278, (Rat) 360406, (Mouse) 19268, (Mouse) 19280, (Rat) 25529

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Function(s)
phosphoprotein phosphatase activity protein tyrosine phosphatase activity transmembrane receptor protein tyrosine phosphatase activity receptor binding protein binding hydrolase activity cell adhesion molecule binding heparin binding chondroitin sulfate proteoglycan binding macromolecular complex binding chondroitin sulfate binding heparan sulfate proteoglycan binding phosphatase activity insulin receptor binding receptor tyrosine kinase binding protein complex binding phosphate ion binding protein phosphatase protein modifying enzyme
Process(es)
phosphate-containing compound metabolic process heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules signal transduction transmembrane receptor protein tyrosine phosphatase signaling pathway nervous system development neuron differentiation negative regulation of JAK-STAT cascade positive regulation of dendrite morphogenesis regulation of immune response modulation of synaptic transmission positive regulation of synapse assembly positive regulation of dendritic spine morphogenesis presynaptic membrane assembly presynapse assembly regulation of postsynaptic density assembly trans-synaptic signaling trans-synaptic signaling by trans-synaptic complex synaptic membrane adhesion cell adhesion regulation of neuron projection development cell migration neuron projection regeneration peptidyl-tyrosine dephosphorylation regulation of axon regeneration negative regulation of receptor binding protein dephosphorylation negative regulation of neuron projection development spinal cord development cerebellum development hippocampus development cerebral cortex development corpus callosum development negative regulation of axon extension negative regulation of interferon-alpha production negative regulation of interferon-beta production negative regulation of toll-like receptor 9 signaling pathway negative regulation of collateral sprouting negative regulation of axon regeneration synapse organization negative regulation of dendritic spine development establishment of endothelial intestinal barrier dephosphorylation negative regulation of cytokine-mediated signaling pathway homophilic cell adhesion via plasma membrane adhesion molecules negative regulation of cell proliferation negative regulation of cell projection organization negative regulation of epidermal growth factor receptor signaling pathway positive regulation of apoptotic process positive regulation of neuron apoptotic process negative regulation of insulin receptor signaling pathway regulation of synapse structure or activity negative regulation of neurotrophin TRK receptor signaling pathway
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