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Antibodies Inc
Navbeta4 Na+ Channel Monoclonal Antibody (N168/6), FL650
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Product Details
75-198-FL650
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N168/6
Immunogen
Fusion protein amino acids 184-228 (cytoplasmic C-terminus) of rat Navbeta4 (accession number Q7M730) produced recombinantly in E. Coli.
Conjugate
Excitation/Emission Max
655/676 nm
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
The SCN4B protein modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. The protein has been found to be expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10) [MIM:611819]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: sodium channel accessory subunit; sodium channel beta 4 subunit; Sodium channel regulatory subunit beta-4; sodium channel subunit beta-4; sodium channel, type 4, beta subunit; sodium channel, type IV, beta; sodium channel, type IV, beta polypeptide; voltage gated sodium channel beta 4 subunit
Gene Aliases: Gm1471; Scn4b
UniProt ID: (Rat) Q7M730, (Mouse) Q7M729
Entrez Gene ID: (Rat) 315611, (Mouse) 399548
sodium ion transport
biological_process
positive regulation of sodium ion transport
regulation of ion transmembrane transport
sodium ion transmembrane transport
cardiac muscle contraction
regulation of ventricular cardiac muscle cell membrane repolarization
cardiac muscle cell action potential involved in contraction
membrane depolarization during cardiac muscle cell action potential
AV node cell to bundle of His cell communication
regulation of heart rate by cardiac conduction
regulation of sodium ion transmembrane transporter activity
transport
ion transport
AV node cell action potential
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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