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Antibodies Inc
Kir2.1 K+ Channel Monoclonal Antibody (N112B/14)
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Product Details
75-210-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N112B/14
Immunogen
Synthetic peptide amino acids 390-411 (cytoplasmic C-terminus) of mouse Kir2.1 (accession number P35561).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4
Contains
0.065% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
The KIR2 subunit family includes 2. 1, 2. 2, 2. 3 and 2. 4. Unlike G protein-coupled KIR3 subunits, KIR2. 1 requires both phosphorylation by PKA and ATP hydrolysis for functional activity. KIR2. 1 is expressed in the superior and inferior collicula and the pontine region of the brain, where it moderates synaptic transmission, like many other potassium channels. In the placenta, KIR2. 1 is expressed throughout gestation in cytotrophoblast cells. In the kidney, KIR2. 1 colocalizes with KIR5. 1 in the proximal tubule. KIR2. 1, 2. 2 and 2. 3 associate with the membrane-associated guanylate kinase synapseassociated protein 97 in the cerebellum and heart. Phosphorylation of KIR2. 2 by protein kinase A inhibits the associates with SAP97.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cardiac inward rectifier potassium channel; HEos-IRK; HHIRK 1; HIRK 1; hIRK1; Inward rectifier K; Inward rectifier K(+) channel Kir2.1; inward rectifier K+ channel KIR2.1; Inward rectifier potassium channel 2; IRK 1; IRK-1; IRK2; LQT 7; Potassium channel, inwardly rectifying subfamily J member 2; potassium channel, inwardly rectifying subfamily J, member 2; potassium inwardly-rectifying channel, subfamily J, member 2; potassium voltage-gated channel subfamily J member 2; RBL-IRK1; SQT 3; unnamed protein product
Gene Aliases: ATFB9; HHBIRK1; HHIRK1; IRK1; Kcnf1; KCNJ2; KIR2.1; LQT7; SQT3
UniProt ID: (Human) P63252, (Rat) Q64273, (Mouse) P35561
Entrez Gene ID: (Human) 3759, (Rat) 29712, (Mouse) 16518
ion transport
potassium ion transport
regulation of skeletal muscle contraction via regulation of action potential
magnesium ion transport
cellular potassium ion homeostasis
ion transmembrane transport
regulation of ion transmembrane transport
protein homotetramerization
relaxation of cardiac muscle
regulation of resting membrane potential
regulation of membrane repolarization
cellular response to mechanical stimulus
potassium ion transmembrane transport
cardiac muscle cell action potential
cardiac muscle cell action potential involved in contraction
regulation of cardiac muscle cell contraction
membrane repolarization during action potential
membrane depolarization during cardiac muscle cell action potential
membrane repolarization during cardiac muscle cell action potential
regulation of heart rate by cardiac conduction
relaxation of skeletal muscle
positive regulation of potassium ion transmembrane transport
potassium ion import across plasma membrane
potassium ion import
regulation of heart rate
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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