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Neuregulin-HBD (Heparin Binding Domain/Type I/II) Monoclonal Antibody (N120A/9), FL650
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Product Details
75-225-FL650
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
N120A/9
Immunogen
Fusion protein amino acids 14-117 (extracellular N-terminus) of human Neuregulin-1 (accession number Q02297) produced recombinantly in E. Coli.
Conjugate
Excitation/Emission Max
655/676 nm
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
Neuregulin-HBD refers to the heparin-binding domain (HBD) of neuregulins, a family of EGF-like signaling proteins involved in cell-cell communication. The heparin-binding domain is crucial for the interaction of neuregulins with heparan sulfate proteoglycans on the cell surface, which can modulate their signaling activity and influence processes such as cell growth, differentiation, and repair. Neuregulins and their HBDs play significant roles in the development and function of the nervous system, heart, and other tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: acetylcholine receptor-inducing activity; glial growth factor 2; growth factor; heregulin, alpha (45kD, ERBB2 p185-activator); neu differentiation factor; neuregulin 1; NRG1; NRG1 class VII isoform alpha 2a; NRG1 class VII isoform alpha 2b; NRG1 class VII isoform alpha beta 2a; NRG1 class VII isoform alpha beta 3; NRG1 class VII isoform beta 2a; NRG1 class VII isoform beta 3; Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1; sensory and motor neuron derived factor; unnamed protein product
Gene Aliases: ARIA; GGF; GGF2; HGL; HRG; HRG1; HRGA; MST131; MSTP131; NDF; NRG1; NRG1-IT2; SMDF
UniProt ID: (Human) Q02297
Entrez Gene ID: (Human) 3084
transcription cofactor activity
receptor binding
cytokine activity
integrin binding
protein binding
growth factor activity
zinc ion binding
nickel cation binding
protein tyrosine kinase activator activity
transmembrane receptor protein tyrosine kinase activator activity
receptor tyrosine kinase binding
ErbB-3 class receptor binding
chemorepellent activity
receptor agonist activity
ventricular trabecula myocardium morphogenesis
cell communication
transmembrane receptor protein tyrosine kinase signaling pathway
nervous system development
brain development
peripheral nervous system development
cell proliferation
positive regulation of cell proliferation
regulation of cell communication
negative regulation of cardiac muscle cell apoptotic process
neural crest cell development
regulation of signaling
cell differentiation
positive regulation of cell growth
mammary gland development
positive regulation of protein complex assembly
activation of protein kinase B activity
intracellular signal transduction
ERBB signaling pathway
ERBB2 signaling pathway
ERBB3 signaling pathway
ERBB4 signaling pathway
ERBB2-ERBB3 signaling pathway
ERBB2-ERBB4 signaling pathway
ERBB4-ERBB4 signaling pathway
wound healing
positive regulation of cell adhesion
negative regulation of transcription, DNA-templated
negative chemotaxis
negative regulation of secretion
positive regulation of developmental process
positive regulation of striated muscle cell differentiation
cardiac muscle cell differentiation
ventricular cardiac muscle cell differentiation
positive regulation of cardiac muscle cell proliferation
cardiac muscle cell myoblast differentiation
endocardial cell differentiation
regulation of biological quality
positive regulation of ERK1 and ERK2 cascade
regulation of postsynaptic neurotransmitter receptor internalization
positive regulation of peptidyl-tyrosine autophosphorylation
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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