Fusion protein amino acids 808-874 (cytoplasmic loop between repeat II and III) of rat Cav1.2 (accession number Q5S007) produced recombinantly in E. Coli.

3D Epitope / Immunogen

Conjugate

FL594 FL594 FL594

Excitation/Emission Max

594/615 nm

Form

Liquid

Concentration

0.5 mg/mL

100 µg

Purification

Protein A

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Dry ice (international)

Product Specific Information

For maximum recovery of product, centrifuge the vial prior to removing the cap.

Target Information

CACNA1C encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by CACNA1C binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: brain class C; CaCB receptor; CACB-receptor; CACH3; CACN4; CACNA 1D; CACNA1C intronic transcript 2; CACNA1C intronic transcript 2 (non-protein coding); CACNL1A2; calcium channel voltage-dependent alpha1c subunit; calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit; Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; calcium channel, voltage-dependent, alpha 1C subunit; calcium channel, voltage-dependent, L type, alpha 1C subunit; CaV1.2; DHP receptor; DHPR, alpha-1 subunit; L-type calcium channel alpha-1 subunit; L-type voltage-dependent calcium channel alpha-1 subunit; long-NT; LTCC; MBC; MELC-CC; MGC120730; Mouse brain class C; neuronal voltage-gated calcium channel alpha 1C subunit; Rat brain class C; RBC; skeletal muscle-specific calcium channel; smooth muscle calcium channel blocker; Smooth muscle calcium channel blocker receptor; unnamed protein product; voltage-dependent L-type Ca2+ channel alpha 1 subunit; Voltage-dependent L-type calcium channel subunit alpha-1C; Voltage-gated calcium channel subunit alpha Cav1.2

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Gene Aliases: CACB; CACH2; CACN2; CACNA1C; CACNA1C-IT2; CACNL1A1; CaV1.2; CCHL1A1; D930026N18Rik; LQT8; MBC; MELC-CC; NEDHLSS; RATIVS302; TS; TS. LQT8

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UniProt ID: (Human) Q13936, (Rabbit) P15381, (Mouse) Q01815, (Guinea pig) O35505, (Rat) P22002

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Entrez Gene ID: (Rabbit) 100144322, (Human) 775, (Rabbit) 100101555, (Mouse) 12288, (Guinea pig) 100135490, (Rat) 24239

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Function(s)

ion channel activity voltage-gated calcium channel activity calcium channel activity protein binding calmodulin binding high voltage-gated calcium channel activity metal ion binding alpha-actinin binding voltage-gated calcium channel activity involved in cardiac muscle cell action potential voltage-gated calcium channel activity involved in AV node cell action potential voltage-gated ion channel activity enzyme binding protein domain specific binding ion channel binding protein phosphatase 2A binding voltage-gated ion channel

Process(es)

immune system development ion transport calcium ion transport muscle contraction positive regulation of cytosolic calcium ion concentration heart development regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ion transmembrane transport embryonic forelimb morphogenesis camera-type eye development positive regulation of adenylate cyclase activity positive regulation of muscle contraction transmembrane transport calcium ion transport into cytosol cardiac conduction calcium ion transmembrane transport via high voltage-gated calcium channel calcium ion transmembrane transport cardiac muscle cell action potential involved in contraction membrane depolarization during cardiac muscle cell action potential membrane depolarization during AV node cell action potential cell communication by electrical coupling involved in cardiac conduction regulation of heart rate by cardiac conduction calcium ion import across plasma membrane regulation of ventricular cardiac muscle cell action potential membrane depolarization during atrial cardiac muscle cell action potential transport cellular calcium ion homeostasis smooth muscle contraction chemical synaptic transmission adult walking behavior regulation of blood pressure visual learning calcium ion regulated exocytosis regulation of vasoconstriction insulin secretion growth hormone secretion regulation of ion transmembrane transport glucose homeostasis regulation of organ growth smooth muscle contraction involved in micturition calcium ion import membrane depolarization during action potential

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Cav1.2 Ca2+ Channel Monoclonal Antibody (N263/31), FL594

Product Details

75-257-FL594

Immunohistochemistry (Frozen) (IHC (F))

Immunocytochemistry (ICC/IF)

ELISA (ELISA)

Species Reactivity

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Excitation/Emission Max

Form

Concentration

Amount

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

References (0)

Bioinformatics

Performance Guarantee

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