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Synaptotagmin-3 Monoclonal Antibody (N278/19), FL650
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Product Details
75-269-FL650
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N278/19
Immunogen
Fusion protein amino acids 442-533 (cytoplasmic C2B domain) of mouse Synaptotagmin-3 (accession number O35681) produced recombinantly in E. Coli.
Conjugate
Excitation/Emission Max
655/676 nm
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
Synaptotagmins are a large gene family of synaptic vesicle type III integral membrane proteins that function as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles. Calcium binds to Synaptotagmin I which triggers neurotransmitter release at the synapse. Synaptotagmin II is phosphorylated by WNK1 in a process that regulates calcium-dependent interactions. Synaptotagmin III is involved in calcium-dependent exocytosis of secretory vesicles in endocrine cells and neurons. Synaptotagmin IV is expressed in neuronal tissues, and has the highest mRNA levels in the hippocampus. The proximity of the Synaptotagmin IV gene to markers of several psychiatric disorders suggest an involvement of synaptotagmin IV in human disease. Synaptotagmin V is a dense-core vesicle-specific protein that regulates a specific type of calcium-regulated secretion. Synaptotagmin VI interacts with adaptor protein-2 in a calcium-independent manner. Synaptotagmin VII is widely expressed in non-neuronal tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: synaptotagmin 3; Synaptotagmin III; Synaptotagmin-3; Synaptotagmin3; SynaptotagminIII; Syt III; SYT-3; SytIII
Gene Aliases: AI385753; SIII; SYT3; SytIII
UniProt ID: (Human) Q9BQG1, (Rat) P40748, (Mouse) O35681
Entrez Gene ID: (Human) 84258, (Rat) 25731, (Mouse) 20981
SNARE binding
protein binding
calcium-dependent phospholipid binding
metal ion binding
calcium ion sensor activity
phosphatidylserine binding
transporter activity
calcium ion binding
syntaxin binding
clathrin binding
identical protein binding
protein homodimerization activity
protein heterodimerization activity
membrane trafficking regulatory protein
chemical synaptic transmission
vesicle-mediated transport
regulation of calcium ion-dependent exocytosis
cell differentiation
positive regulation of vesicle fusion
positive regulation of dendrite extension
synaptic vesicle exocytosis
calcium ion regulated exocytosis
response to calcium ion
calcium ion-regulated exocytosis of neurotransmitter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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