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Antibodies Inc
SUR1/SUR2B Monoclonal Antibody (N323A/31)
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Product Details
75-298
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N323A/31
Immunogen
Fusion protein amino acids 1503-1545 of rat SUR2B (accession number Q63563-2) produced recombinantly in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4
Contains
0.065% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Sequence of this protein is as follows: VHTILTADLV IVMKRGNILE YDTPESLLAQ EDGVFASFVR ADM
Target Information
Sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of anti-diabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inward-rectifier potassium ion channels Kir6.x (6.1 and 6.2). The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel. The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADP and in response facilitate the open or closing its associated Kir6.x potassium channel. Hence the KATP channel monitors the energy balance within the cell.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABC36; ABC37; ATFB12; ATP-binding cassette sub-family C member 8; ATP-binding cassette sub-family C member 9; ATP-binding cassette transporter sub-family C member 8; ATP-binding cassette transporter sub-family C member 9; ATP-binding cassette, sub-family C (CFTR/MRP), member 8; ATP-binding cassette, sub-family C (CFTR/MRP), member 9; CANTU; CMD1O; FLJ36852; HHF1; HI; HRINS; MRP8; PHHI; sulfonylurea receptor; Sulfonylurea receptor 1; Sulfonylurea receptor 2; sulfonylurea-binding protein 2; sulphonylurea receptor 1; SUR1delta2; TNDM2
Gene Aliases: Abcc8; Abcc9; AI414027; AI449286; D930031B21Rik; Sur; SUR1; Sur2; SUR2A; SUR2B
UniProt ID: (Rat) Q09429, (Rat) Q63563, (Mouse) P70170
Entrez Gene ID: (Mouse) 20927, (Rat) 25559, (Rat) 25560, (Mouse) 20928
potassium channel activity
ATP binding
syntaxin binding
ion channel binding
sulfonylurea receptor activity
ATPase activity, coupled to transmembrane movement of substances
drug binding
potassium channel regulator activity
identical protein binding
nucleotide binding
ATPase activity
ATP-binding cassette (ABC) transporter
response to pH
response to zinc ion
positive regulation of potassium ion transport
negative regulation of insulin secretion
cellular response to organic substance
potassium ion transmembrane transport
potassium ion transport
signal transduction
metabolic process
response to lipopolysaccharide
response to insulin
response to drug
transmembrane transport
substrate-dependent cell migration, cell contraction
potassium ion import
defense response to virus
transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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