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SUR1/SUR2B Monoclonal Antibody (N323A/31)

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SUR1/SUR2B Monoclonal Antibody (N323A/31)

Product Details

75-298

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

N323A/31

Immunogen

Fusion protein amino acids 1503-1545 of rat SUR2B (accession number Q63563-2) produced recombinantly in E. Coli.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4

Contains

0.065% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Dry ice (international)

Product Specific Information

For maximum recovery of product, centrifuge the vial prior to removing the cap.

Sequence of this protein is as follows: VHTILTADLV IVMKRGNILE YDTPESLLAQ EDGVFASFVR ADM

Target Information

Sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of anti-diabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inward-rectifier potassium ion channels Kir6.x (6.1 and 6.2). The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel. The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADP and in response facilitate the open or closing its associated Kir6.x potassium channel. Hence the KATP channel monitors the energy balance within the cell.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ABC36; ABC37; ATFB12; ATP-binding cassette transporter sub-family C member 8; ATP-binding cassette transporter sub-family C member 9; ATP-binding cassette, sub-family C (CFTR/MRP), member 8; ATP-binding cassette, sub-family C (CFTR/MRP), member 9; ATP-binding cassette, sub-family C, member 9-like; ATP-binding cassette, subfamily C (CFTR/MRP), member 8; ATP-binding cassette, subfamily C (CFTR/MRP), member 9; CANTU; CMD1O; FLJ36852; HHF1; HI; HRINS; K-ATP channel subunit; MRP8; PHHI; sulfonylurea receptor; sulfonylurea receptor 1; Sulfonylurea receptor 2; sulfonylurea receptor 2 protein; sulfonylurea-binding protein 2; sulphonylurea receptor 1; SUR1delta2; TNDM2; unnamed protein product

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Gene Aliases: D930031B21Rik; Sur; SUR1; Sur2; SUR2A; SUR2B

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UniProt ID: (Rat) Q09429, (Rat) Q63563, (Mouse) P70170

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Entrez Gene ID: (Mouse) 20927, (Rat) 25559, (Rat) 25560, (Mouse) 20928

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Function(s)
potassium channel activity ATP binding zinc ion binding sulfonylurea receptor activity ATPase activity cation-transporting ATPase activity ADP binding ion channel binding ABC-type transporter activity inward rectifier potassium channel activity protein binding potassium channel regulator activity transmembrane transporter activity ATPase activity, coupled to transmembrane movement of substances macromolecular complex binding potassium channel activator activity heterocyclic compound binding identical protein binding
Process(es)
MAPK cascade action potential blood vessel development response to hypoxia heart morphogenesis vascular process in circulatory system regulation of transcription from RNA polymerase II promoter potassium ion transport substrate-dependent cell migration, cell contraction response to stress mitochondrion organization heart development skeletal muscle tissue development blood circulation regulation of blood pressure response to xenobiotic stimulus gene expression response to activity fatty acid oxidation response to ATP response to potassium ion cellular response to potassium ion response to decreased oxygen levels vasodilation regulation of membrane potential response to hydrogen peroxide negative regulation of apoptotic process response to estrogen cellular respiration negative regulation of blood pressure ATP metabolic process fibroblast proliferation defense response to virus transmembrane transport coronary vasculature development cardiac conduction cellular response to chemical stress response to oxygen levels cellular response to calcium ion cellular response to ATP cellular response to xenobiotic stimulus potassium ion transmembrane transport circulatory system development oxygen metabolic process cardiac muscle cell contraction regulation of blood vessel diameter cation transmembrane transport regulation of potassium ion transmembrane transport response to peptide reactive oxygen species biosynthetic process response to hydrogen sulfide potassium ion import across plasma membrane cellular glucose homeostasis female pregnancy memory visual learning response to pH response to zinc ion negative regulation of low-density lipoprotein particle clearance negative regulation of angiogenesis cellular response to nutrient levels response to lipopolysaccharide positive regulation of tumor necrosis factor production response to insulin positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of potassium ion transport negative regulation of insulin secretion negative regulation of neurogenesis regulation of insulin secretion neuromuscular process negative regulation of glial cell proliferation glutamate secretion, neurotransmission negative regulation of neuroblast migration positive regulation of uterine smooth muscle relaxation positive regulation of voltage-gated potassium channel activity positive regulation of occluding junction disassembly negative regulation of blood-brain barrier permeability
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