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Antibodies Inc
MAP3K12 Monoclonal Antibody (N377/20), FL490
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Product Details
75-355-FL490
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
N377/20
Immunogen
Fusion protein amino acids 727-888 (C-terminus) of mouse MAP3K12 (accession number Q60700) produced recombinantly in E. Coli.
Conjugate
Excitation/Emission Max
491/515 nm
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
ZPK is a member of serine/threonine protein kinase family. This kinase contains a leucine-zipper domain, and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DLK; Dual leucine zipper bearing kinase; dual leucine zipper kinase; Leucine-zipper protein kinase; M3KC; MAPK-upstream kinase; Mitogen activated protein kinase 12 (Zipper (leucine) protein kinase); mitogen activated protein kinase kinase kinase 12; Mitogen-activated protein kinase kinase kinase 12; Mixed lineage kinase; MUK; Zipper (leucine) protein kinase; ZPK
Gene Aliases: DLK; Map3k12; MUK; PK; Zpk
UniProt ID: (Rat) Q63796, (Mouse) Q60700
Entrez Gene ID: (Rat) 25579, (Mouse) 26404
protein serine/threonine kinase activity
MAP kinase kinase kinase activity
ATP binding
protein kinase binding
protein homodimerization activity
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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