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Pan-Kvbeta Potassium Channel Monoclonal Antibody (K25/73), FL550

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Pan-Kvbeta Potassium Channel Monoclonal Antibody (K25/73), FL550

Product Details

75-392-FL550

Applications
Tested Dilution
Publications

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

K25/73

Immunogen

Synthetic peptide amino acids 350-367 of human Kvbeta2 (accession number Q13303).
View immunogen

Conjugate

FL550 FL550 FL550

Excitation/Emission Max

550/575 nm

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Dry ice (international)

Product Specific Information

For maximum recovery of product, centrifuge the vial prior to removing the cap.

Sequence of this protein is as follows: EIDSILGNKP YSKKDYRS

Target Information

KVbeta1, KVbeta2, and KVbeta3 are beta subunits of voltage-gated potassium (KV) channels. These auxiliary subunits modulate the properties and functions of the KV channel's alpha subunits. These KVbeta subunits are essential for the fine-tuning of KV channel activity, impacting the electrical properties of cells and contributing to the regulation of physiological processes such as neuronal signaling and cardiac rhythm.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alternative splice product of the Shaker beta 1 gene, see GenBank Accession Numbers U16953 and L39833; hKvbeta2; K(+) channel subunit beta-1; K(+) channel subunit beta-2; K(+) channel subunit beta-3; K+ channel Beta1a chain; KCNAB2; Kv-beta-1; Kv-beta-2; Kv-beta-3; Neuroimmune protein F5; potassium channel beta 3 chain; potassium channel beta3 subunit; potassium channel shaker chain beta 1a; potassium channel subunit; potassium channel, voltage gated shaker-related subfamily A regulatory beta subunit 2; potassium channel, voltage gated shaker-related subfamily A regulatory beta subunit 3; potassium channel, voltage gated subfamily A regulatory beta subunit 1; potassium channel, voltage gated subfamily A regulatory beta subunit 2; potassium channel, voltage gated subfamily A regulatory beta subunit 3; potassium channel, voltage-dependent, beta-3 subunit; potassium voltage gated channel shaker related subfamily beta member 1; potassium voltage gated channel, shaker related subfamily, beta member 1; potassium voltage gated channel, shaker related subfamily, beta member 2; potassium voltage gated channel, shaker related subfamily, beta member 3; potassium voltage-gated channel subfamily A member regulatory beta subunit 1; potassium voltage-gated channel, shaker-related subfamily, beta member 1; potassium voltage-gated channel, shaker-related subfamily, beta member 2; potassium voltage-gated channel, shaker-related subfamily, beta member 3; RCK beta3; shaker-related subfamily member 1; unnamed protein product; voltage-gated potassium channel beta subunit; Voltage-gated potassium channel subunit beta-1; Voltage-gated potassium channel subunit beta-2; Voltage-gated potassium channel subunit beta-3

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Gene Aliases: AKR6A3; AKR6A5; AKR6A9; Akr8a8; C330022D06Rik; Ckbeta2; Ckbeta3; F5; hKvb3; HKvbeta2; HKvbeta2.1; HKvbeta2.2; hKvBeta3; I2rf5; KCNA1B; KCNA2B; KCNA3.1B; KCNA3B; KCNAB1; KCNAB2; KCNAB3; Kcnab4; Kcnb3; KCNK2; KV-BETA-1; KV-BETA-2; KV-BETA-3; Kvb1; Kvb1.3; Kvbeta1.1; KvBeta3; mKv(beta)1; mKv(beta)4

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UniProt ID: (Human) Q14722, (Human) Q13303, (Human) O43448, (Mouse) P63143, (Rat) P63144, (Mouse) P62482, (Rat) P62483, (Rat) Q63494

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Entrez Gene ID: (Human) 7881, (Human) 8514, (Human) 9196, (Mouse) 16497, (Rat) 29737, (Mouse) 16498, (Rat) 29738, (Rat) 58981, (Mouse) 16499

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Function(s)
carbonyl reductase (NADPH) activity voltage-gated potassium channel activity protein binding alcohol dehydrogenase (NADP+) activity potassium channel regulator activity oxidoreductase activity protein domain specific binding ion channel binding NADPH binding molecular function inhibitor activity methylglyoxal reductase (NADPH) (acetol producing) activity C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity aldo-keto reductase (NADP) activity isocitrate dehydrogenase activity mevaldate reductase activity voltage-gated ion channel activity gluconate dehydrogenase activity steroid dehydrogenase activity epoxide dehydrogenase activity 5-exo-hydroxycamphor dehydrogenase activity 2-hydroxytetrahydrofuran dehydrogenase activity acetoin dehydrogenase activity phenylcoumaran benzylic ether reductase activity D-xylose:NADP reductase activity L-arabinose:NADP reductase activity D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor steroid dehydrogenase activity, acting on the CH-CH group of donors (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity 3-hydroxymenthone dehydrogenase activity very long-chain-3-hydroxyacyl-CoA dehydrogenase activity dihydrotestosterone 17-beta-dehydrogenase activity (R)-2-hydroxyisocaproate dehydrogenase activity L-arabinose 1-dehydrogenase (NADP+) activity L-xylulose reductase (NAD+) activity 3-ketoglucose-reductase activity (R)-2-hydroxyglutarate dehydrogenase activity D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity
Process(es)
ion transport potassium ion transport ion transmembrane transport potassium ion transmembrane transport regulation of potassium ion transmembrane transport learning or memory transmembrane transport regulation of delayed rectifier potassium channel activity negative regulation of voltage-gated potassium channel activity regulation of ion transmembrane transport transport hematopoietic progenitor cell differentiation neuromuscular process protein heterooligomerization oxidation-reduction process NADPH oxidation regulation of protein localization to cell surface regulation of potassium ion transmembrane transporter activity negative regulation of delayed rectifier potassium channel activity
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