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SK2 potassium channel Monoclonal Antibody (K78/29), FL490
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Product Details
75-403-FL490
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
K78/29
Immunogen
Synthetic peptide amino acids 546-562 of rat SK2 (accession number P70604).
Conjugate
Excitation/Emission Max
491/515 nm
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Sequence of this protein is as follows: ENYDKHVTYN AERSRSS
Target Information
Action potentials in vertebrate neurons are followed by an afterhyperpolarization that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: apamin-sensitive small-conductance Ca2+-activated potassium channel; ion channel; KCa2.2; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2; SK2; SKCa 2; SKCa2; small conductance calcium-activated channel, subfamily N, member 2; small conductance calcium-activated potassium channel 2; Small conductance calcium-activated potassium channel protein 2; small conductance calcium-activated potassium channel subfamily N member 2; unnamed protein product
Gene Aliases: DYT34; fri; hSK2; KCa2.2; KCNN2; NEDMAB; SK2; SKCa 2; SKCA2
UniProt ID: (Human) Q9H2S1, (Rat) P70604, (Mouse) P58390
Entrez Gene ID: (Human) 3781, (Rat) 54262, (Mouse) 140492
inward rectifier potassium channel activity
protein binding
calmodulin binding
calcium-activated potassium channel activity
small conductance calcium-activated potassium channel activity
protein domain specific binding
protein homodimerization activity
alpha-actinin binding
ion channel activity
voltage-gated ion channel
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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