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Antibodies Inc
TrpM6 Monoclonal Antibody (N470/22)
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Product Details
75-464
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
N470/22
Immunogen
Fusion protein amino acids 1258-1480 (cytoplasmic C-terminus) of human TrpM6 (accession number Q9BX84) produced recombinantly in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4
Contains
0.065% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
TRPM6 is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. TRPM6 is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Further, TRPM6 is an essential ion channel and serine/threonine-protein kinase, and is crucial for magnesium homeostasis. TRPM6 has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region. Mutations in TRPM6 are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. TRPC7 is thought to form a receptor-activated non-selective calcium permeant cation channel. TRPC7 is probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. TRPC7 is also activated by diacylglycerol (DAG). Further, TRPC7 may also be activated by intracellular calcium store depletion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ChaK2; protein kinase/ion channel; Channel kinase 2; Melastatin-related TRP cation channel 6; Transient receptor potential cation channel subfamily M member 6; transient receptor potential cation channel subfamily M member 6 variant; TRPM6a; TRPM6a-t; TRPM6b; TRPM6c; unnamed protein product
Gene Aliases: CHAK2; HMGX; HOMG; HOMG1; HSH; TRPM6
UniProt ID: (Human) Q9BX84
Entrez Gene ID: (Human) 140803
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
ion channel activity
cation channel activity
calcium channel activity
protein binding
ATP binding
calcium ion transmembrane transporter activity
magnesium ion transmembrane transporter activity
kinase activity
transferase activity
metal ion binding
protein serine kinase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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