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VAPA/B Monoclonal Antibody (N479/107), FL650
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Product Details
75-496-FL650
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
N479/107
Immunogen
Fusion protein amino acids 1-219 (N-terminus) of rat VAPA (accession number Q9Z270) produced recombinantly in E. Coli.
Conjugate
FL650
FL650
FL650
Excitation/Emission Max
655/676 nm
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
VAPA/VAPB may play a role in vesicle trafficking. Present in the plasma membrane and in intracellular vesicles. Interacts with VAMP1 and VAMP2. Subunit: Homodimer, and heterodimer with VAPA. Subcellular Location: Cell membrane; Single-pass type IV membrane protein. Intracytoplasmic membrane; Single-pass type IV membrane protein. Tissue Specificity: Ubiquitous. Isoform 1 predominates. Disease: Defects in VAPB are the cause of amyotrophic lateral sclerosis type 8 (ALS8). ALS8 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms. Defects in VAPB are a cause of proximal adult autosomal dominant spinal muscular atrophy; also called late-onset spinal muscular atrophy Finkel type. Spinal muscular atrophies are neurodegenerative disorders characterized by degeneration of lower motor neurons, leading to progressive paralysis muscular atrophy. This form is a late- adult-onset form of the disease (after age 20 years). The patients show a benign course, most of them remaining ambulatory 10 to 40 years after clinical onset.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 33 kDa VAMP-associated protein; similar to Aplysia VAP333; synaptobrevin-associated protein of 33kDa; unnamed protein product; VAMP (vesicle-associated membrane protein)-associated protein A; VAMP (vesicle-associated membrane protein)-associated protein B and C; VAMP-A; VAMP-associated protein 33b; VAMP-associated protein A; VAMP-associated protein B; VAP-33; VAP-A; VAP33a; VAP33b; vesicle-associated membrane protein, associated protein a; vesicle-associated membrane protein, associated protein B and C
Gene Aliases: 33kDa; D2Abb2e; VAMP-A; VAMP-B; Vamp33b; VAP-33; VAP-A; VAP-B; VAP33; VAP33b
UniProt ID: (Mouse) Q9WV55, (Rat) Q9Z270, (Rat) Q9Z269
Entrez Gene ID: (Mouse) 30960, (Rat) 58857, (Mouse) 56491, (Rat) 60431
cellular calcium ion homeostasis
ER to Golgi vesicle-mediated transport
endoplasmic reticulum organization
viral release from host cell
cholesterol transport
endoplasmic reticulum unfolded protein response
IRE1-mediated unfolded protein response
negative regulation by host of viral release from host cell
negative regulation by host of viral genome replication
positive regulation by host of viral genome replication
modulation by host of viral RNA genome replication
positive regulation of viral genome replication
negative regulation by virus of viral protein levels in host cell
COPII-coated vesicle budding
endoplasmic reticulum membrane organization
sphingomyelin biosynthetic process
phospholipid transport
sterol transport
neuron projection development
ceramide transport
cholesterol homeostasis
protein localization to endoplasmic reticulum
protein folding in endoplasmic reticulum
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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