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MAVS/VISA Recombinant Rabbit Monoclonal Antibody (7F14)

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MAVS/VISA Recombinant Rabbit Monoclonal Antibody (7F14)

Product Details

81910-1-RR

Applications
Tested Dilution
Publications

Western Blot (WB)

1:5,000-1:50,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:2,000
-

Immunocytochemistry (ICC/IF)

1:500-1:2,000
-

ELISA (ELISA)

Assay-dependent
-

Immunoprecipitation (IP)

0.5-4 µg/1-3 mg of protein lysate
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

Mammalian cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

7F14

Immunogen

Recombinant protein
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Protein A

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: MPFAEDKTYK YICRNFSNFC NVDVVEILPY LPCLTARDQD RLRATCTLSG NRDTLWHLFN TLQRRPGWVE YFIAALRGCE LVDLADEVAS VYESYQPRTS DRPPDPLEPP SLPAERPGPP TPAAAHSIPY NSCREKEPSY PMPVQETQAP ESPGENSEQA LQTLSPRAIP RNPDGGPLES SSDLAALSPL TSSGHQEKDT ELGSTHTAGA TSSLTPSRGP VSPSVSFQPL ARSTPRASRL PGPTGSVVST GTSFSSSSPG LASAGAAEGK QGAESDQAEP IICSSGAEAP ANSLPSKVPT TLMPVNTVAL KVPANPASVS TVPSKLPTSS KPPGAVPSNA LTNPAPS

Target Information

Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. MAVS is a mitochondrial membrane protein that was identified as a critical component in the IFN beta signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappa-B. MAVS is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. MAVS also interacts with the IKK-alpha, IKK-beta and IKK-iota kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. Multiple isoforms of MAVS are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CARD adapter inducing interferon beta; CARD adaptor inducing IFN-beta; Cardif; IFN-B promoter stimulator 1; Interferon beta promoter stimulator protein 1; IPS-1; MAVS; Mitochondrial antiviral-signaling protein; Putative NF-kappa-B-activating protein 031N; unnamed protein product; virus-induced signaling adaptor; Virus-induced-signaling adapter; VISA; VISA1a; VISA1b

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Gene Aliases: CARDIF; IPS-1; IPS1; KIAA1271; MAVS; VISA

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UniProt ID: (Human) Q7Z434

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Entrez Gene ID: (Human) 57506

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Function(s)
protein binding protein kinase binding protein binding, bridging signaling adaptor activity identical protein binding CARD domain binding binding, bridging protein serine/threonine kinase binding DNA-binding transcription factor binding molecular condensate scaffold activity
Process(es)
activation of innate immune response positive regulation of defense response to virus by host immune system process positive regulation of myeloid dendritic cell cytokine production cytoplasmic pattern recognition receptor signaling pathway signal transduction mRNA transcription positive regulation of type I interferon production positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production intracellular signal transduction positive regulation of protein import into nucleus defense response to bacterium positive regulation of I-kappaB kinase/NF-kappaB signaling NLRP3 inflammasome complex assembly negative regulation of viral genome replication innate immune response positive regulation of transcription from RNA polymerase II promoter defense response to virus type I interferon signaling pathway positive regulation of type I interferon-mediated signaling pathway positive regulation of response to cytokine stimulus protein localization to mitochondrion cellular response to exogenous dsRNA positive regulation of chemokine (C-C motif) ligand 5 production positive regulation of IP-10 production antiviral innate immune response regulation of peroxisome organization positive regulation of NLRP3 inflammasome complex assembly
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