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CISD2 Recombinant Rabbit Monoclonal Antibody (6H13)
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FIGURE: 1 / 6
CISD2 Antibody (82802-10-RR) in ICC/IF
Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using CISD2 antibody (82802-10-RR, Clone: 6H13) at dilution of 1:400 and Multi-rAb CoraLite ® Plus 488-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR002), CL594-phalloidin (red).
Product Details
82802-10-RR
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
6H13
Immunogen
CISD2 fusion protein Ag4172
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
25 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: PKKKQQKDSL INLKIQKENP KVVNEINIED LCLTKAAYCR CWRSKTFPAC DGSHNKHNEL TGDNVGPLIL KKKEV
Target Information
Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDGSH iron sulfur domain-containing protein 2; CDGSH iron-sulfur domain-containing protein 2; Endoplasmic reticulum intermembrane small protein; Miner1; mitoNEET related 1; MitoNEET-related 1 protein; NAF-1; nervous system over-expressed protein 70; Nervous system overexpressed protein 70; Nutrient-deprivation autophagy factor-1; unnamed protein product; zinc finger, CDGSH-type domain 2
Gene Aliases: 1500009M05Rik; 1500026J14Rik; 1500031D15Rik; AI848398; B630006A20Rik; CDGSH2; CISD2; ERIS; Miner1; NAF-1; Noxp70; WFS2; ZCD2
UniProt ID: (Human) Q8N5K1, (Mouse) Q9CQB5
Entrez Gene ID: (Human) 493856, (Mouse) 67006
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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