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Proteintech
CYP7B1 Recombinant Rabbit Monoclonal Antibody (230160H5)
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Product Details
82927-1-RR
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
230160H5
Immunogen
CYP7B1 fusion protein Ag19374
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: PFQYQLVIKN HKQLSFRVFS NKLLEKAFSI SQLQKNHDMN DELHLCYQFL QGKSLDILLE SMMQNLKQVF EPQLLKTTSW DTAELYPFCS SIIFEITFTT IYGKVIVCDN NKFISELRDD FLKFDDKFAY LVSNIPIELL GNVKSIREKI IKCFSSEKLA KMQGWSEVFQ SRQDVLEKYY VHEDLEIGAH HLGFLWASVA NTIPTMFWAM YYLLRHPEAM AAVRDEIDRL LQSTGQKKGS GFPIHLTREQ LDSLICLESS IFEALRLSSY STTIRFVEED LTLSSETGDY CVRKGDLVAI FPPVLHGD
Target Information
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 24-hydroxycholesterol 7-alpha-hydroxylase; 25-hydroxycholesterol 7-alpha-hydroxylase; 25/26-hydroxycholesterol 7-alpha-hydroxylase; 3-hydroxysteroid 7-alpha hydroxylase; cytochrome p450; Cytochrome P450 7B1; cytochrome P450, subfamily VIIB (oxysterol 7 alpha-hydroxylase), polypeptide 1; Oxysterol 7-alpha-hydroxylase
Gene Aliases: CBAS3; CP7B; CYP7B1; SPG5A
UniProt ID: (Human) O75881
Entrez Gene ID: (Human) 9420
monooxygenase activity
iron ion binding
protein binding
steroid hydroxylase activity
oxysterol 7-alpha-hydroxylase activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
heme binding
24-hydroxycholesterol 7alpha-hydroxylase activity
25-hydroxycholesterol 7alpha-hydroxylase activity
metal ion binding
lipid metabolic process
steroid biosynthetic process
bile acid biosynthetic process
steroid metabolic process
cholesterol metabolic process
sterol metabolic process
intracellular estrogen receptor signaling pathway
negative regulation of intracellular estrogen receptor signaling pathway
B cell chemotaxis
cholesterol homeostasis
epithelial cell proliferation
positive regulation of epithelial cell proliferation
prostate gland epithelium morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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