Proteintech

GDNF Recombinant Rabbit Monoclonal Antibody (230358A10)

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Datasheet
Protocols
Questions & Answers
Tech Support
Datasheet
Protocols
Questions & Answers
Tech Support
GDNF Recombinant Rabbit Monoclonal Antibody (230358A10)

Product Details

83087-1-RR

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:2,000
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:250
-

Immunocytochemistry (ICC/IF)

1:50-1:500
-

Flow Cytometry (Flow)

0.25 µg/10^6 cells in a 100 µL suspension
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

CHO cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

230358A10

Immunogen

GDNF fusion protein Ag24068
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: SPDKQMAVLP RRERNRQAAA ANPENSRGKG RRGQRGKNRG CVLTAIHLNV TDLGLGYETK EELIFRYCSG SCDAAETTYD KILKNLSRNR RLVSDKVGQA CCRPIAFDDD LSFLDDNLVY HILRKHSAKR CGCI

Target Information

GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. GDNF is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Astrocyte-derived trophic factor; ATF; Glial cell line-derived neurotrophic factor; H-GDNF; hGDNF; mGDNF; neurotrophic factor

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Gene Aliases: AI385739; ATF1; ATF2; GDNF; HFB1-GDNF; HSCR3

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UniProt ID: (Human) P39905, (Mouse) P48540

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Entrez Gene ID: (Human) 2668, (Mouse) 14573

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Function(s)
Ras guanyl-nucleotide exchange factor activity receptor binding protein binding growth factor activity protein homodimerization activity transforming growth factor beta receptor binding glial cell-derived neurotrophic factor receptor binding neurotrophic factor
Process(es)
MAPK cascade metanephros development branching involved in ureteric bud morphogenesis neural crest cell migration organ induction postsynaptic membrane organization mesenchymal to epithelial transition involved in metanephros morphogenesis signal transduction nervous system development positive regulation of cell proliferation adult locomotory behavior regulation of gene expression postganglionic parasympathetic fiber development peristalsis neuron projection development positive regulation of monooxygenase activity positive regulation of dopamine secretion negative regulation of apoptotic process negative regulation of neuron apoptotic process positive regulation of GTPase activity positive regulation of cell differentiation positive regulation of transcription from RNA polymerase II promoter mRNA stabilization enteric nervous system development sympathetic nervous system development regulation of dopamine uptake involved in synaptic transmission ureteric bud formation regulation of morphogenesis of a branching structure positive regulation of ureteric bud formation positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis positive regulation of branching involved in ureteric bud morphogenesis regulation of stem cell differentiation negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ureteric bud development transmembrane receptor protein tyrosine kinase signaling pathway transforming growth factor beta receptor signaling pathway peripheral nervous system development cell proliferation response to wounding neuron differentiation cellular response to dexamethasone stimulus regulation of ureteric bud formation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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