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GenScript
C-peptide Monoclonal Antibody (4C2F10)
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FIGURE: 1 / 1
C-peptide Antibody (A01784-1) in ELISA
Antibody pairs analysis of C-peptide monoclonal antibodies by Sandwich ELISA: General procedures: 1. Microplate was coated with a capture antibody against C-peptide, followed by 3 washing cycles. 2. Incubation with C-peptide followed by 3 washing cycles. 3. Incubation with Biotin conjugated detection antibody against C-peptide, followed by 3 washing cycles. 4. Incubation with Streptaidin-HRP, followed by 3 washing cycles. Colorimetric determination of bound peroxidase activity.
Product Details
A01784-1
Product Specifications
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
4C2F10
Immunogen
human C-peptide conjugated to KLH.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
1 mg
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Wet ice
Product Specific Information
C-peptide serves as an important linker between A-chain and B-chain of insulin and facilitates the efficient assembly, folding, and processing of insulin in the endoplasmic reticulum. Equimolar amounts of C-peptide and insulin are stored in secretory granules of the pancreatic beta cells and both are eventually released to the portal circulation. The sole interest in C-peptide was as a marker of insulin secretion. Newly diagnosed diabetes patients often get their C-peptide levels measured as a means of distinguishing type 1 and type 2 diabetes. C-peptide is also used for determining the possibility of gastrinomas associated with Multiple Endocrine Neoplasm syndromes (MEN 1). GenScript Human C-Peptide Antibody, mAb, Mouse is produced from the hybridoma resulting from fusion of SP2/0-Ag14 myeloma and B-lymphocytes obtained from mouse immunized with human C-peptide conjugated to KLH.
Target Information
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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