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GenScript
Tocilizumab Monoclonal Antibody (6C10), Biotin
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FIGURE: 1 / 2
Tocilizumab Antibody (A01980-40) in ELISA
Standard curve of Tocilizumab Sandwich ELISA. The Tocilizumab Sandwich ELISA assay is developed by using Anti-Tocilizumab Antibody (14B10), mAb, Mouse (GenScript, A01978-40) and Anti-Tocilizumab Antibody (6C10), mAb, Mouse (GenScript, A01980-40) as the capture and detection antibodies, respectively The sensitivity is less than 100 pg/mL.
Product Details
A01980-40
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
6C10
Immunogen
Tocilizumab
Conjugate
Form
Lyophilized
Amount
40 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute the lyophilized antibody with deionized water (or equivalent) to a final concentration of 0.5 mg/mL.
Tocilizumab also known as atlizumab, is a humanized monoclonal antibody that is approved by the U.S. Food and Drug Administration. It has a high affinity to IL-6R and blocks the IL-6 signaling by preventing the formation of the IL-6/IL-6R complex. Tocilizumab is used for the treatment of rheumatoid arthritis (RA) and systemic juvenile idiopathic arthritis, a severe form of arthritis in children. Anti-Tocilizumab Antibody (6C10), mAb, Mouse is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with Tocilizumab.
Upon reconstitution, it can be stored for 2-3 weeks at 2-8 °C or for up to 12 months at -20 °C or below.
Target Information
Interleukin 6 receptor (IL6R), also known as CD126 (Cluster of Differentiation 126), is a type I cytokine receptor. This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD126; CD126 antigen; gp80; IL-6 Receptor; il-6 receptor alpha; IL-6 receptor subunit alpha; IL-6R 1; ILN; Interleukin; Interleukin-6 receptor subunit alpha; Membrane glycoprotein 80; MGC104991; unnamed protein product
Gene Aliases: CD126; gp80; HIES5; IL-1Ra; IL-6R; IL-6R-1; IL-6RA; IL6Q; IL6QTL; IL6R; IL6RA; IL6RQ
UniProt ID: (Human) P08887
Entrez Gene ID: (Human) 3570
cytokine receptor activity
ciliary neurotrophic factor receptor activity
interleukin-6 receptor activity
interleukin-11 receptor activity
interleukin-6 receptor binding
protein binding
enzyme binding
interleukin-11 binding
interleukin-6 binding
protein homodimerization activity
ciliary neurotrophic factor binding
hepatic immune response
neutrophil mediated immunity
monocyte chemotaxis
positive regulation of leukocyte chemotaxis
acute-phase response
JAK-STAT cascade
positive regulation of cell proliferation
vascular endothelial growth factor production
cytokine-mediated signaling pathway
endocrine pancreas development
developmental process
negative regulation of interleukin-8 production
positive regulation of chemokine production
positive regulation of interleukin-6 production
negative regulation of collagen biosynthetic process
response to cytokine
interleukin-11-mediated signaling pathway
positive regulation of MAPK cascade
positive regulation of osteoblast differentiation
positive regulation of smooth muscle cell proliferation
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
interleukin-6-mediated signaling pathway
ciliary neurotrophic factor-mediated signaling pathway
positive regulation of glomerular mesangial cell proliferation
T-helper 17 cell lineage commitment
extrinsic apoptotic signaling pathway
receptor signaling pathway via STAT
positive regulation of platelet aggregation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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