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Invitrogen
CD35 Monoclonal Antibody (E11), FITC
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Product Details
A15455
Product Specifications
Species Reactivity
Baboon,
Chimpanzee,
Cynomolgus monkey,
Human,
Rhesus monkey
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
E11
Immunogen
Human CD35 from Acute monocytic leukemia cells and normal blood monocytes
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.1 mg/mL
Amount
100 µg
Purification
purified
Storage buffer
PBS, pH 7.4
Contains
<0.1% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
CD35 (CR1, Complement Receptor 1) is a cell membrane-bound, monomeric glycoprotein and its primary function is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. CD35 protein mediates cellular binding to particles and immune complexes that have activated complement. The CD35 complex is four different allotypes (C,A,B,D) C is 160 kDa; A is 190 kDa; B is 220 kDa and D is 250 kDa. CD35 is involved in the processing of immune complexes, promoting of binding and phagocytosis of C3b complexes and inhibition of complement activation. CD35 is on neutrophils, eosinophils, monocytes, B-cells, some NK-cells, erythrocytes, myeloid leukemias, follicular dendritic reticulum cells and is negative on basophils. Decreases in expression of CD35 protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in the CD35 gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants encoding different isoforms of CD35 have been characterized. An additional secreted form of CD35 have also been described but has not been fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C3 binding protein; C3-binding protein; C3b/C4b receptor; CD35; CD35 antigen; complement component (3b/4b) receptor 1 (Knops blood group); Complement Component (3b/4b) receptor 1 including Knops blood group system; complement component receptor 1-like protein; complement receptor 1; Complement receptor type 1; cr1 (CD35); CR1 receptor; Knops blood group antigen; unnamed protein product
Gene Aliases: C3BR; C4BR; CD35; CR1; KN
UniProt ID: (Human) P17927
Entrez Gene ID: (Cynomolgus monkey) 102117401, (Rhesus monkey) 718120, (Human) 1378, (Chimpanzee) 449643
positive regulation of activation of membrane attack complex
negative regulation of activation of membrane attack complex
immune system process
complement receptor mediated signaling pathway
immune complex clearance by erythrocytes
T cell mediated immunity
negative regulation of immunoglobulin production
complement activation, alternative pathway
complement activation, classical pathway
plasma membrane organization
positive regulation of cell proliferation
regulation of complement activation
negative regulation of interferon-gamma production
negative regulation of interleukin-2 production
negative regulation of T cell proliferation
innate immune response
positive regulation of regulatory T cell differentiation
negative regulation of complement activation
negative regulation of complement activation, alternative pathway
negative regulation of complement activation, classical pathway
viral entry into host cell
negative regulation of serine-type endopeptidase activity
positive regulation of serine-type endopeptidase activity
negative regulation of plasma cell differentiation
regulation of complement-dependent cytotoxicity
negative regulation of complement-dependent cytotoxicity
ATP export
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