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Invitrogen
KIR2DL4 Monoclonal Antibody (#33), PE
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FIGURE: 1 / 1
KIR2DL4 Antibody (A15790) in Flow
Flow Cytometry analysis of KIR2DL4 using KIR2DL4 Monoclonal Antibody (mAb#33), PE (Product # A15790). Separation of cells stained using anti-human CD158d (mAb#33) PE antibody (20 μl reagent per million cells in 100 μl of cell suspension, red-filled) from cells stained using mouse IgG1 isotype control (MOPC-21) PE antibody (concentration in sample 7.5 μg/mL, same as CD158d PE concentration, black-dashed) in flow cytometry analysis (surface staining) of NKL cell suspension.
Product Details
A15790
Product Specifications
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
#33
Immunogen
NK33 cells and KIR2DL4-Ig fusion protein
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody recognizes extracellular portion of CD158d / KIR2DL4, a 45 kDa NK cell marker. Cell surface expression and function of CD158d / KIR2DL4 depends on genotype of particular individuals.
Target Information
CD158d / KIR2DL4 is a KIR family member that shares structural features with both activating and inhibitory receptors and may mediate different functions under different circumstances. It contains cytoplasmic ITIM, suggesting inhibitory function, but also transmembrane domain similar to those of activating KIRs. It has been reported that CD158d serves as an inhibitory receptor for peripheral and uterine NK cells, but its ligation with soluble mAbs (unlike immobilized mAbs) results in activation of IFN-gamma secretion. CD158d also binds both membrane form and soluble form of its ligand HLA-G.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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