Search
Invitrogen
CD148 Monoclonal Antibody (MEM-CD148/05), PE
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
{{$ctrl.translations['antibody.pdp.skuNotes.additionalInformation']}}:
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
A15799
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
MEM-CD148/05
Immunogen
Human recombinant CD148 (amino acids 1-444)
Conjugate
PE
PE
PE
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Purification
Size-exclusion chromatography
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
15mM sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody recognizes an extracellular epitope of CD148, a highly glycosylated up to 250 kDa receptor-like protein tyrosine phosphatase expressed mainly in lymphocytes, myeloid cells and epithelial cells.
Target Information
CD148 is a highly glycosylated transmembrane protein of up to 250 kDa, containing eight fibronectin type III domains in the extracellular region and one tyrosine phosphatase domain in the cytoplasmic region. Expression is found broadly on fibroblasts, epithelial cells, lymphocytes (B, T and NK cells), and myeloid cells (monocytes and granulocytes). CD148 can dephosphorylate proteins such as LAT and PLC-gamma, and is involved in the downregulation of T cell activation. Conversely, CD148 expression can be upregulated following T cell activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
How to use the Panel Builder
Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.
Bioinformatics
Protein Aliases: CD148 antigen; density-enhanced phosphatase 1; human density enhanced phosphatase-1; protein tyrosine phosphatase, receptor type, J polypeptide; protein-tyrosine phosphatase eta; susceptibility to colon cancer 1, mouse, homolog of
Gene Aliases: CD148; DEP1; HPTP eta; HPTPeta; R-PTP-ETA; R-PTP-J; SCC1; THC10
UniProt ID: (Human) Q12913
Entrez Gene ID: (Human) 5795
positive regulation of cell-matrix adhesion
immune system process
signal transduction
axon guidance
negative regulation of cell proliferation
anatomical structure morphogenesis
negative regulation of platelet-derived growth factor receptor signaling pathway
cytokine-mediated signaling pathway
hemopoiesis
regulation of cell adhesion
B cell differentiation
platelet formation
negative regulation of cell growth
negative regulation of cell migration
positive regulation of tumor necrosis factor production
peptidyl-tyrosine dephosphorylation
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of vascular permeability
negative regulation of MAP kinase activity
positive regulation of MAPK cascade
positive regulation of cell adhesion
platelet-derived growth factor receptor signaling pathway
positive regulation of phagocytosis
positive regulation of immune response
positive regulation of calcium-mediated signaling
T cell receptor signaling pathway
negative regulation of T cell receptor signaling pathway
positive chemotaxis
positive regulation of cellular component organization
positive regulation of focal adhesion assembly
positive regulation of protein kinase B signaling
negative regulation of protein kinase B signaling
contact inhibition
positive regulation of Fc receptor mediated stimulatory signaling pathway
positive regulation of intracellular signal transduction
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support