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Invitrogen

CD148 Monoclonal Antibody (MEM-CD148/05), PE

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CD148 Monoclonal Antibody (MEM-CD148/05), PE

Product Details

A15799

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

10 µL/1x10^6 cells
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

MEM-CD148/05

Immunogen

Human recombinant CD148 (amino acids 1-444)
3D Epitope / Immunogen

Conjugate

PE PE PE

Excitation/Emission Max

565/576 nm View spectra spectra

Form

Liquid

Purification

Size-exclusion chromatography

Storage buffer

PBS, pH 7.4, with 0.2% BSA

Contains

15mM sodium azide

Storage conditions

4°C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2534577

Product Specific Information

This antibody recognizes an extracellular epitope of CD148, a highly glycosylated up to 250 kDa receptor-like protein tyrosine phosphatase expressed mainly in lymphocytes, myeloid cells and epithelial cells.

Target Information

CD148 is a highly glycosylated transmembrane protein of up to 250 kDa, containing eight fibronectin type III domains in the extracellular region and one tyrosine phosphatase domain in the cytoplasmic region. Expression is found broadly on fibroblasts, epithelial cells, lymphocytes (B, T and NK cells), and myeloid cells (monocytes and granulocytes). CD148 can dephosphorylate proteins such as LAT and PLC-gamma, and is involved in the downregulation of T cell activation. Conversely, CD148 expression can be upregulated following T cell activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

How to use the Panel Builder

Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

Bioinformatics

Protein Aliases: CD148; CD148 antigen; Density-enhanced phosphatase 1; DEP-1; HPTP eta; human density enhanced phosphatase-1; protein tyrosine phosphatase, receptor type, J polypeptide; Protein-tyrosine phosphatase eta; Protein-tyrosine phosphatase receptor type J; R-PTP-J; Receptor-type tyrosine-protein phosphatase eta; susceptibility to colon cancer 1, mouse, homolog of

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Gene Aliases: CD148; DEP1; HPTP eta; HPTPeta; PTPRJ; R-PTP-ETA; R-PTP-J; SCC1; THC10

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UniProt ID: (Human) Q12913

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Entrez Gene ID: (Human) 5795

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Function(s)
phosphoprotein phosphatase activity protein tyrosine phosphatase activity platelet-derived growth factor receptor binding protein binding beta-catenin binding hydrolase activity phosphatase activity protein kinase binding gamma-catenin binding cadherin binding mitogen-activated protein kinase binding delta-catenin binding
Process(es)
angiogenesis vasculogenesis positive regulation of cell-matrix adhesion immune system process signal transduction axon guidance heart development blood coagulation negative regulation of cell proliferation anatomical structure morphogenesis positive regulation of platelet activation negative regulation of platelet-derived growth factor receptor signaling pathway positive regulation of macrophage chemotaxis cytokine-mediated signaling pathway hemopoiesis regulation of cell adhesion B cell differentiation platelet formation negative regulation of cell growth negative regulation of cell migration positive regulation of tumor necrosis factor production peptidyl-tyrosine dephosphorylation negative regulation of epidermal growth factor receptor signaling pathway glucose homeostasis negative regulation of vascular permeability negative regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of cell adhesion negative regulation of insulin receptor signaling pathway platelet-derived growth factor receptor signaling pathway oligodendrocyte differentiation positive regulation of phagocytosis positive regulation of immune response positive regulation of calcium-mediated signaling T cell receptor signaling pathway negative regulation of T cell receptor signaling pathway positive chemotaxis positive regulation of cellular component organization positive regulation of focal adhesion assembly positive regulation of protein kinase B signaling negative regulation of protein kinase B signaling contact inhibition positive regulation of Fc receptor mediated stimulatory signaling pathway regulation of biological quality positive regulation of intracellular signal transduction
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