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Bethyl Laboratories
RCH1/KPNA2 Polyclonal Antibody
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FIGURE: 1 / 1
RCH1/KPNA2 Antibody (A300-484A-M) in WB
Detection of human and mouse RCH1/KPNA2 by western blot. Samples: Whole cell lysate from HeLa (5, 15, and 50 µg), 293T (50 µg), and mouse NIH3T3 (50 µg) cells. Antibody: Affinity purified rabbit anti-RCH1/KPNA2 antibody A300-484A-M used at 1:1000. Detection: Chemiluminescence with an exposure time of 30 seconds.
Product Details
A300-484A-M
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 475 and the C-terminus (residue 529) of Human RAG cohort 1 (Karyopherin Alpha 2).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Storage conditions
4°C
Shipping conditions
Wet ice
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1, which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in VJ recombination.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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