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Bethyl Laboratories
TLK2 Polyclonal Antibody
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FIGURE: 1 / 2
TLK2 Antibody (A301-257A) in WB
Detection of human TLK2 by western blot. Samples: Whole cell lysate from HEK293T (50, 15 and 5 µg) and HeLa (50 µg) cells. Antibody: Affinity purified rabbit anti-TLK2 antibody (Product # A301-257A lot 1) used for WB at 0.4 µg/mL. Detection: Chemiluminescence with an exposure time of 30 seconds.
Product Details
A301-257A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 722 and 772 of Human tousled-like kinase 2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
TLK2 or Tousled-like kinase 2, is a nuclear serine/threonine kinases that is thought to be involved in the regulation of chromatin assembly. In addition, TLK2 is also involved in other cellular processes such as intracellular signaling cascade, protein amino acid phosphorylation, cell cycle, chromatin modification and in response to DNA damage stimulus. TLK2 displays maximal activity during S phase of the cell cycle where it appears to be regulated by cell-cycle-dependent phosphorylation. Inhibition of DNA replication causes a rapid loss of TLK2 activity, indicating that TLK2 function is tightly linked to ongoing DNA replication. The TLK2 enzyme is cell-cycle regulated, with maximal activity in S-phase. It is inactivated by phosphorylation at Ser-750, potentially by CHK1. TLK2 heterodimerizes with TLK1. This nuclear protein is widely expressed, with presence in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle tissues, and in several adult cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HsHPK; PKU-alpha; serine/threonine protein kinase; Serine/threonine-protein kinase tousled-like 2; Tousled-like kinase 2; unnamed protein product
Gene Aliases: HsHPK; MRD57; PKU-ALPHA; TLK2
UniProt ID: (Human) Q86UE8
Entrez Gene ID: (Human) 11011
chromatin organization
protein phosphorylation
cellular response to DNA damage stimulus
chromosome segregation
negative regulation of autophagy
peptidyl-serine phosphorylation
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
intracellular signal transduction
nucleus localization
cellular response to gamma radiation
regulation of chromatin organization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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