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Bethyl Laboratories
MINK1 Polyclonal Antibody
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FIGURE: 1 / 1
MINK1 Antibody (A302-191A-T) in WB
Detection of human and mouse MINK1 by western blot (h&m) and immunoprecipitation (h). Samples: Whole cell lysate from HeLa (5, 15 and 50 µg for WB; 1 mg for IP, 20% of IP loaded) and mouse NIH 3T3 (M; 50 µg) cells. Antibodies: Affinity purified rabbit anti-MINK1 antibody (Product # A302-191A) used for WB at 0.04 µg/mL (A) and 1 µg/mL (B) and used for IP at 3 µg/mg lysate. MINK1 was also immunoprecipitated by rabbit anti-MINK1 antibodies A302-192A and A302-193A, which recognize downstream epitopes. Detection: Chemiluminescence with exposure... View More
Product Details
A302-191A-T
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 1 and 50 of human misshapen-like kinase 1.
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Amount
2 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
MINK1 is a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ18426; FLJ38123; FLJ94103; GCK family kinase MINK; hMINK; hMINKbeta; ISK; JLNS; JLNS2; LQT2/5; LQT5; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6; MGC33114; Mink 1; Mink 2; mink1; Misshapen-like kinase 1; Misshapen/NIK-related kinase; Misshapen/NIKs-related kinase; Mitogen-activated protein kinase kinase kinase kinase 6; Yeast Sps1/Ste20-related kinase 2
Gene Aliases: B55; MAP4K6; MEKKK 6; MINK; MINK1; YSK2; ZC3
UniProt ID: (Human) Q8N4C8, (Mouse) Q9JM52
Entrez Gene ID: (Human) 50488, (Mouse) 50932
MAPK cascade
regulation of cell-matrix adhesion
protein phosphorylation
JNK cascade
chemical synaptic transmission
brain development
regulation of cell-cell adhesion
actin cytoskeleton organization
regulation of cell migration
intracellular signal transduction
regulation of MAPK cascade
regulation of JNK cascade
positive regulation of JNK cascade
protein autophosphorylation
neuron projection morphogenesis
dendrite morphogenesis
positive regulation of p38MAPK cascade
positive regulation of intracellular signal transduction
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
response to stress
regulation of mitotic cell cycle
phosphorylation
stress-activated protein kinase signaling cascade
actin cytoskeleton reorganization
activation of protein kinase activity
regulation of apoptotic process
negative thymic T cell selection
neuron cellular homeostasis
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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