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Bethyl Laboratories

Beta-Arrestin 2 Polyclonal Antibody

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Beta-Arrestin 2 Polyclonal Antibody

Product Details

A303-785A-T

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Immunohistochemistry (IHC)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:2,000
-

Immunoprecipitation (IP)

2-10 µg/mg lysate
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Region between residue 310 and 360 of human Arrestin, Beta 2.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

10 µg

Purification

Antigen affinity chromatography

Storage buffer

phosphate/tris citrate, pH 7-8

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Based on 100% sequence identity, this antibody is predicted to react with Orangutan

Target Information

Beta-arrestin-2, or ARRB2, is an adaptor protein belonging to the arrestin family with an N- arrestin domain and a C- arrestin domain. ARRB2 is a regulatory protein involved in heterotrimeric G protein-coupled receptor desensitization and is known to regulate beta2-adrenergic receptor (beta2AR) function by enhancing beta2AR mediated nuclear translocation of ERK. ARRB2 binds to phosphorylated beta2ARs, thereby causing a significant impairment of their capacity to activate G(S) proteins. Along with AIP4, ARRB2 acts as an endosomal sorting molecule that mediates CXCR4 entry into a degradative pathway. It may also be involved in hormone-specific desensitization of TSH receptors. ARRB2 is a Ca2+ binding protein of the retinal outer segments and binds to P-rhodopsin and is also involved in synaptic transmission in photoreceptor cells. It is widely expressed in most of the tissues, especially neuronal tissues and spleen.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: activated GPCR interaction protein; ARRB2; arrestin 3; Arrestin beta-2; Beta-arrestin-2; Non-visual arrestin-3; unnamed protein product

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Gene Aliases: ARB2; ARR2; ARRB2; BARR2

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UniProt ID: (Human) P32121

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Entrez Gene ID: (Human) 409

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Function(s)
G-protein coupled receptor binding receptor binding protein binding enzyme binding protein binding, bridging ubiquitin protein ligase binding angiotensin receptor binding D1 dopamine receptor binding protein kinase B binding binding, bridging
Process(es)
desensitization of G-protein coupled receptor protein signaling pathway G-protein coupled receptor internalization positive regulation of receptor internalization transcription from RNA polymerase II promoter signal transduction transforming growth factor beta receptor signaling pathway I-kappaB kinase/NF-kappaB signaling adult walking behavior regulation of G-protein coupled receptor protein signaling pathway negative regulation of signal transduction positive regulation of cardiac muscle hypertrophy positive regulation of gene expression protein transport protein ubiquitination sensory perception of pain negative regulation of protein ubiquitination receptor internalization negative regulation of NF-kappaB transcription factor activity positive regulation of synaptic transmission, dopaminergic negative regulation of interleukin-1 beta production negative regulation of interleukin-12 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production negative regulation of toll-like receptor signaling pathway negative regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of natural killer cell mediated cytotoxicity modulation of synaptic transmission positive regulation of protein kinase B signaling negative regulation of protein kinase B signaling excitatory postsynaptic potential cell chemotaxis positive regulation of ERK1 and ERK2 cascade postsynaptic signal transduction beta-arrestin-dependent dopamine receptor signaling pathway positive regulation of intracellular signal transduction positive regulation of cardiac muscle cell differentiation
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