Immunogen sequence: EWAFEESKID EHHFVAVALR KPDGSRHQDV PSQDDSKPTQ RQFTILNFND LMSSAVPMTP EDPSFWDCFC FTEEIPIRNG TKS
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 88%.
The protein encoded by this gene is similar to Saccharomyces cerevisiae LYS5, which is required for the activation of the alpha-aminoadipate dehydrogenase in the biosynthetic pathway of lysine. Yeast alpha-aminoadipate dehydrogenase converts alpha-biosynthetic-aminoadipate semialdehyde to alpha-aminoadipate. It has been suggested that defects in the human gene result in pipecolic acidemia.
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Protein Aliases: 4'-phosphopantetheinyl transferase; AASD-PPT; Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase; holo ACP synthase; holo-[acyl-carrier-protein] synthase; L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; LYS2; LYS5; LYS5 ortholog
Gene Aliases: 2010309J24Rik; 2810407B07Rik; AASD-PPT; AASDHPPT; ACPS; CGI-80; HAH-P; HSPC223; LYS2; LYS5; x0005
Molecular Function: transferase