The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.
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Protein Aliases: Apoptosis-antagonizing transcription factor; Protein AATF; Rb-binding protein Che-1; Traube protein
Gene Aliases: 4933415H02Rik; 5830465M17Rik; AATF; BFR2; CHE-1; CHE1; DED; HSPC277; Trb
Molecular Function: chromatin/chromatin-binding, or -regulatory protein