PA5-27405 targets ABAT in WB applications and shows reactivity with Human and mouse samples.
The PA5-27405 immunogen is recombinant fragment corresponding to a region within amino acids 302 and 500 of Human ABAT.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
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Protein Aliases: (S)-3-amino-2-methylpropionate transaminase; 4-aminobutyrate aminotransferase, brain isoform; 4-aminobutyrate aminotransferase, liver isoform; 4-aminobutyrate aminotransferase, mitochondrial; 4-aminobutyrate transaminase; beta-alanine oxoglutarate aminotransferase; GABA aminotransferase; GABA transaminase; GABA transferase; GABA-AT; GABA-T; GABAT; Gamma-amino-N-butyrate transaminase; L-AIBAT; mitochondrial; NPD009
Gene Aliases: 9630038C02Rik; ABAT; AI255750; beta-AlaAT; ENSMUSG00000051226; GABA-AT; Gabaat; GABAT; Gm9851; I54; Laibat; NPD009; X61497