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Invitrogen
ABCA4 Polyclonal Antibody
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FIGURE: 1 / 4
ABCA4 Antibody (PA5-87983) in WB
Western blot analysis of ABCA4 in mouse eye. Samples were incubated with ABCA4 Polyclonal antibody (Product # PA5-87983) using a dilution of 1:500, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-87983
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
1.55 mg/mL
Amount
155 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: U-251MG, BT-474, 293T, Mouse heart, Mouse lung, Rat eye; Cellular Location: Membrane, Multi-pass membrane protein
Immunogen sequence: QELLMNAPES QHLGRIWTEL HILSQFMDTL RTHPERIAGR GIRIRDILKD EETLTLFLIK NIGLSDSVVY LLINSQVRPE QFAHGVPDLA LKDIACSEAL LERFIIFSQR RGAKTVRYAL CSLSQGTLQW IEDTLYANVD FFKLFRVLPT LLDSRSQGIN LRSWGGILSD MSPRIQEFIH RPSMQDLLWV T
Target Information
ABCA4 (ATP-Binding Cassette, Subfamily A, Member 4), also known as ABCR, is a protein which in humans is encoded by the ABCA4 gene. ABCA4 is a member of the ATP-binding cassette transporter gene sub-family A (ABC1) found exclusively in multicellular eukaryotes. Using a whole genome radiation hybrid panel, this gene is mapped to 1p21-p13. And this gene is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Additionally, it is showed by immunofluorescence microscopy and Western blot analysis that ABCR is present in foveal and peripheral cone, as well as rod, photoreceptors. The results suggested that the loss in central vision experienced by patients with Stargardt macular dystrophy arises directly from ABCR-mediated foveal cone degeneration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ABC transporter superfamily; ATP binding cassette transporter; ATP-binding cassette 10; ATP-binding cassette sub-family A member 4; ATP-binding cassette transporter, retinal-specific; ATP-binding cassette, sub-family A (ABC1), member 4; ATP-binding transporter, retina-specific; photoreceptor rim protein; retina-specific ABC transporter; Retinal-specific ATP-binding cassette transporter; Retinal-specific phospholipid-transporting ATPase ABCA4; RIM ABC transporter; RIM protein; RIM proteinv; Stargardt disease protein; unnamed protein product
Gene Aliases: ABC10; ABCA4; ABCR; ARMD2; AW050280; CORD3; D430003I15Rik; FFM; RMP; RP19; STGD; STGD1
UniProt ID: (Human) P78363, (Mouse) O35600
Entrez Gene ID: (Human) 24, (Mouse) 11304, (Rat) 310836
nucleotide binding
GTPase activity
retinoid binding
11-cis retinal binding
all-trans retinal binding
ATP binding
phospholipid transporter activity
hydrolase activity
ATPase activity
retinol transporter activity
ATPase activity, coupled to transmembrane movement of substances
phosphatidylethanolamine flippase activity
ATPase-coupled intramembrane lipid transporter activity
flippase activity
N-retinylidene-phosphatidylethanolamine flippase activity
ABC-type transporter activity
phospholipid-translocating ATPase activity
transporter activity
cholesterol transporter activity
molecular_function
ATP-binding cassette (ABC) transporter
primary active transporter
transporter
retinoid metabolic process
phospholipid transfer to membrane
lipid transport
visual perception
phototransduction, visible light
organic hydroxy compound transport
retinol transport
retinal metabolic process
phospholipid translocation
photoreceptor cell maintenance
transmembrane transport
transport
cholesterol efflux
phospholipid efflux
response to stimulus
biological_process
metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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