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ABCA4 Rim Protein Monoclonal Antibody (3F4)
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FIGURE: 1 / 1
ABCA4 Rim Protein Antibody (200-301-D05) in IHC (P)
Immunohistochemistry of Anti-ABCA4 (Rim Protein) (Mouse) Antibody. Tissue: adult mouse retina. Fixation: formalin fixed paraffin embedded. Antigen retrieval: not required. Primary antibody: ABCA4 antibody at 10 µg/mL for 1 hr at RT. Secondary antibody: Peroxidase mouse secondary antibody at 1:10,000 for 45 min at RT. Localization: ABCA4 is extra- and intracellular membranes. Staining: ABCA4 as precipitated ... View More
Product Details
200-301-D05
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Xenopus
Host/Isotype
Mouse
/ IgG
Class
Monoclonal
Type
Antibody
Clone
3F4
Immunogen
Anti-ABCA4 antibody was produced by repeated immunizations with 220-kDa (full length) partially purified native bovine disc rim protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
10mM HEPES, pH 7.5, with 150mM NaCl, 50% glycerol, 0.1mg/mL BSA
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
ABCA4 (ATP-Binding Cassette, Subfamily A, Member 4), also known as ABCR, is a protein which in humans is encoded by the ABCA4 gene. ABCA4 is a member of the ATP-binding cassette transporter gene sub-family A (ABC1) found exclusively in multicellular eukaryotes. Using a whole genome radiation hybrid panel, this gene is mapped to 1p21-p13. And this gene is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Additionally, it is showed by immunofluorescence microscopy and Western blot analysis that ABCR is present in foveal and peripheral cone, as well as rod, photoreceptors. The results suggested that the loss in central vision experienced by patients with Stargardt macular dystrophy arises directly from ABCR-mediated foveal cone degeneration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABC transporter superfamily; ATP binding cassette transporter; ATP-binding cassette 10; ATP-binding cassette sub-family A member 4; ATP-binding cassette transporter, retinal-specific; ATP-binding cassette, sub-family A (ABC1), member 4; ATP-binding cassette, sub-family A, member 4; ATP-binding transporter, retina-specific; photoreceptor rim protein; retina-specific ABC transporter; retinal ABCA4 transporter; Retinal-specific ATP-binding cassette transporter; Retinal-specific phospholipid-transporting ATPase ABCA4; RIM ABC transporter; RIM protein; RIM proteinv; Stargardt disease protein; unnamed protein product
Gene Aliases: ABC10; ABCA4; ABCR; ARMD2; AW050280; CORD3; D430003I15Rik; FFM; RMP; RP19; STGD; STGD1; XELAEV_180233141mg
UniProt ID: (Human) P78363, (Bovine) F1MWM0, (Mouse) O35600
Entrez Gene ID: (Human) 24, (Bovine) 281584, (Mouse) 11304, (Xenopus) 497268
nucleotide binding
GTPase activity
retinoid binding
11-cis retinal binding
all-trans retinal binding
ATP binding
phospholipid transporter activity
hydrolase activity
ATPase activity
retinol transporter activity
ATPase activity, coupled to transmembrane movement of substances
phosphatidylethanolamine flippase activity
ATPase-coupled intramembrane lipid transporter activity
flippase activity
N-retinylidene-phosphatidylethanolamine flippase activity
ABC-type transporter activity
phospholipid-translocating ATPase activity
transporter activity
cholesterol transporter activity
ATP-binding cassette (ABC) transporter
primary active transporter
transporter
retinoid metabolic process
phospholipid transfer to membrane
lipid transport
visual perception
phototransduction, visible light
organic hydroxy compound transport
retinol transport
retinal metabolic process
phospholipid translocation
photoreceptor cell maintenance
transmembrane transport
transport
cholesterol efflux
phospholipid efflux
response to stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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