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Invitrogen
ABCA5 Polyclonal Antibody
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Product Details
PA5-103633
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ABCA5(Accession Q8WWZ7), corresponding to amino acid residues H884-S934.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total ABCA5.
Target Information
ABCA5 (ATP-binding cassette, sub-family A (ABC1), member 5) is a 1,642 amino acid protein belonging to the ABC transporter superfamily and the ABCA family. The ABC1 subfamily is the only major ABC subfamily exclusive to multicellular eukaryotes. Ubiquitously expressed, with high expression in testis, skeletal muscle, kidney, liver and placenta, ABCA5 is a multi-pass membrane protein that contains two ABC transporter domains and exists as three alternatively spliced isoforms. ABCA5 exhibits membrane subcellular localization and may play a role in processing autolysosomes. Spanning 80 kb, ABCA5 contains 39 exons, with exon 2 containing the putative translation start site. ABCA5 is the first of five ABC1 family members that maps to human chromosome 17q24. ABCA5 is linked to lysosomal diseases and may play a role in tumor development and cardiomyocyte and follicular cell activities. ABCA5 might also be a specific urine marker for diagnosis of patients with high-grade prostatic intraepithelial neoplasia (HGPIN).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABC-A5; ATP-binding cassette A5; ATP-binding cassette sub-family A member 5; ATP-binding cassette transporter sub-family A member 5; ATP-binding cassette, sub-family A (ABC1), member 5; Cholesterol transporter ABCA5; DKFZp451F117; DKFZp779N2435; FLJ16381; unnamed protein product
Gene Aliases: ABC13; ABCA5; B930033A02Rik; DEL17q24; EST90625; HTC3; HTGH; KIAA1888; mKIAA1888
UniProt ID: (Human) Q8WWZ7, (Mouse) Q8K448, (Rat) Q8CF82
Entrez Gene ID: (Human) 23461, (Mouse) 217265, (Rat) 286970
lipid transport
cholesterol metabolic process
negative regulation of macrophage derived foam cell differentiation
regulation of cholesterol efflux
cholesterol efflux
high-density lipoprotein particle remodeling
cholesterol homeostasis
reverse cholesterol transport
transmembrane transport
positive regulation of reverse cholesterol transport
transport
metabolic process
sterol transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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