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Proteintech
ABCA7 Polyclonal Antibody
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Product Details
25339-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.36 mg/mL
Amount
54 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Target Information
ATP-binding cassette (ABC) transporters are an evolutionarily conserved family that use ATP hydrolysis to catalyze the transport of various molecules across cell membranes. They are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). ABCA7, a member of the ABC1 subfamily, is a full-size ABC transporter consisting of two sets of the multiple membrane-spanning domains plus the Walker motifs for the ATP interaction. ABCA7 shows the highest homology to ABCA1, an essential molecule for cholesterol homeostasis. The high expression levels of ABCA7 in peripheral leukocytes, thymus, spleen and bone marrow suggests a role in the immune system lipid homeostasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ABC 1 antibody; ABC Transporter 1; ABC1; ABC1 antibody; ABCA-SSN; ABCA7; ABCA7 protein; ATP-binding cassette sub-family A member 7; ATP-binding cassette, sub-family A (ABC1), member 7; ATP-binding cassette, sub-family A, member 7; Autoantigen SS-N; CERP; CERP antibody; EC 2.2.1.1; EC 3.6.3; EC 3.6.3.41; FLJ40025; Macrophage ABC transporter; Phospholipid-transporting ATPase ABCA7; unnamed protein product
Gene Aliases: Abc51; ABCA-SSN; ABCA7; ABCX; AD9
UniProt ID: (Human) Q8IZY2, (Rat) Q7TNJ2, (Mouse) Q91V24
Entrez Gene ID: (Human) 10347, (Rat) 299609, (Mouse) 27403
nucleotide binding
ATP binding
phospholipid transporter activity
ATPase activity
apolipoprotein A-I receptor activity
ATPase activity, coupled to transmembrane movement of substances
phosphatidylcholine-translocating ATPase activity
phosphatidylserine-translocating ATPase activity
ATPase-coupled intramembrane lipid transporter activity
floppase activity
ABC-type transporter activity
transporter activity
protein binding
cholesterol transporter activity
ATP-binding cassette (ABC) transporter
primary active transporter
transporter
lipid transport
phagocytosis
memory
visual learning
positive regulation of cholesterol efflux
regulation of lipid metabolic process
cholesterol efflux
phospholipid efflux
beta-amyloid formation
high-density lipoprotein particle assembly
protein localization to nucleus
apolipoprotein A-I-mediated signaling pathway
negative regulation of amyloid precursor protein biosynthetic process
negative regulation of MAPK cascade
plasma membrane raft organization
phospholipid translocation
negative regulation of endocytosis
positive regulation of phagocytosis
transmembrane transport
positive regulation of ERK1 and ERK2 cascade
amyloid-beta clearance by cellular catabolic process
positive regulation of beta-amyloid clearance
positive regulation of engulfment of apoptotic cell
negative regulation of beta-amyloid formation
regulation of amyloid precursor protein catabolic process
positive regulation of phospholipid efflux
negative regulation of PERK-mediated unfolded protein response
positive regulation of protein localization to cell surface
phospholipid scrambling
peptide cross-linking
negative regulation of ATPase activity
positive regulation of ATPase activity
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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