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OriGene

ABCB1 Polyclonal Antibody

View all (109) P-Glycoprotein (ABCB1) antibodies

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Product Details

TA890095

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein of human ABCB1

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.45 mg/mL

Amount

245 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1); ATP-binding cassette sub-family B member 1; ATP-binding cassette sub-family B member 1A; ATP-binding cassette sub-family B member 1B; ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1); ATP-binding cassette, sub-family B (MDR/TAP), member 1A; ATP-binding cassette, sub-family B (MDR/TAP), member 1B; ATP-binding cassette, sub-family B (MDR/TAP), member 4; ATP-binding cassette, subfamily B (MDR/TAP), member 1A; ATP-binding cassette, subfamily B, member 1A; ATP-binding cassette, subfamily B, member 1B; ATP-dependent translocase ABCB1; CD243; colchicin sensitivity; doxorubicin resistance; ecotropic viral integration site 32; MDR1; P-glycoprotein; MDR1A; multi-drug resistance 3; Multidrug resistance protein 1; Multidrug resistance protein 1A; Multidrug resistance protein 1B; Multidrug resistance protein 3; multidrug-resistance; multiple drug resistant 1a; P glycoprotein 1; P glycoprotein 3; P-glycoprotein; P-glycoprotein 1; P-glycoprotein 3; P-glycoprotein/multidrug resistance 1; Phospholipid transporter ABCB1; unnamed protein product; uORF

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Gene Aliases: ABC20; ABCB1; Abcb1a; Abcb1b; Abcb4; CD243; CLCS; ENPAT; Evi32; GP170; mdr; mdr-3; MDR1; Mdr1a; Mdr1b; Mdr3; p-170; P-GP; Pgp; Pgy-1; Pgy-3; PGY1; Pgy1-1; Pgy3

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UniProt ID: (Human) P08183, (Mouse) P21447, (Mouse) P06795

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Entrez Gene ID: (Human) 5243, (Mouse) 18671, (Rat) 170913, (Mouse) 18669, (Rat) 24646

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Function(s)
nucleotide binding protein binding ATP binding xenobiotic-transporting ATPase activity efflux transmembrane transporter activity ATPase activity transmembrane transporter activity ubiquitin protein ligase binding ATPase activity, coupled to transmembrane movement of substances xenobiotic transporter activity carboxylic acid transmembrane transporter activity phosphatidylcholine-translocating ATPase activity phosphatidylethanolamine flippase activity ceramide floppase activity ATPase-coupled intramembrane lipid transporter activity floppase activity ABC-type transporter activity hydrolase activity ATPase activity, coupled transporter activity drug transmembrane transporter activity ATP-binding cassette (ABC) transporter
Process(es)
G2/M transition of mitotic cell cycle response to hypoxia placenta development xenobiotic metabolic process lipid transport female pregnancy lactation circadian rhythm response to xenobiotic stimulus hormone transport response to mycotoxin response to nutrient levels response to estradiol response to lipopolysaccharide response to progesterone response to vitamin A response to vitamin D response to glucagon maintenance of blood-brain barrier cellular response to mycotoxin daunorubicin transport phospholipid translocation response to cadmium ion terpenoid transport intestinal absorption transmembrane transport establishment of blood-brain barrier transepithelial transport cellular response to external biotic stimulus cellular response to lipopolysaccharide cellular response to antibiotic cellular response to alkaloid cellular response to tumor necrosis factor cellular response to estradiol stimulus cellular hyperosmotic salinity response response to dexamethasone cellular response to dexamethasone stimulus stem cell proliferation response to thyroxine response to alcohol response to antineoplastic agent ceramide translocation export across plasma membrane transport across blood-brain barrier response to L-glutamate protein localization to bicellular tight junction response to glycoside negative regulation of sensory perception of pain cellular response to nonylphenol positive regulation of establishment of Sertoli cell barrier regulation of intestinal absorption carboxylic acid transmembrane transport cellular response to borneol cellular response to L-glutamate response to codeine response to quercetin response to cyclosporin A drug transmembrane export drug transport across blood-brain barrier establishment of blood-retinal barrier positive regulation of response to drug regulation of chloride transport transport drug transmembrane transport drug transport xenobiotic transport drug export negative regulation of cell death metabolic process response to organic cyclic compound response to drug cellular response to organic cyclic compound establishment of endothelial blood-brain barrier response to ionizing radiation response to arsenic-containing substance response to steroid hormone
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